Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1995468..1995970 Replicon chromosome
Accession NZ_CP097360
Organism Escherichia coli strain AGR4587

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag M7749_RS09485 Protein ID WP_000767822.1
Coordinates 1995716..1995970 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag M7749_RS09480 Protein ID WP_001259255.1
Coordinates 1995468..1995719 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7749_RS09455 (1990646) 1990646..1991713 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
M7749_RS09460 (1991713) 1991713..1992783 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
M7749_RS09465 (1992780) 1992780..1994084 - 1305 WP_001546022.1 histidinol dehydrogenase -
M7749_RS09470 (1994090) 1994090..1994989 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
M7749_RS09475 (1995135) 1995135..1995185 - 51 WP_001364200.1 his operon leader peptide -
M7749_RS09480 (1995468) 1995468..1995719 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
M7749_RS09485 (1995716) 1995716..1995970 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
M7749_RS09490 (1996053) 1996053..1996877 + 825 WP_000754737.1 SDR family oxidoreductase -
M7749_RS09495 (1996923) 1996923..1997852 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
M7749_RS09500 (1998067) 1998067..1998129 + 63 WP_010723108.1 membrane protein YoeI -
M7749_RS09505 (1998119) 1998119..1999477 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T245271 WP_000767822.1 NZ_CP097360:1995716-1995970 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT245271 WP_001259255.1 NZ_CP097360:1995468-1995719 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References