Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3643308..3643983 Replicon chromosome
Accession NZ_CP097342
Organism Enterobacter hormaechei subsp. xiangfangensis strain va18651

Toxin (Protein)


Gene name higB Uniprot ID A0A7T9SGM4
Locus tag M5K26_RS17430 Protein ID WP_032654718.1
Coordinates 3643308..3643607 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2J0PXC9
Locus tag M5K26_RS17435 Protein ID WP_015571639.1
Coordinates 3643618..3643983 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5K26_RS17420 (M5K26_17395) 3639685..3641877 + 2193 WP_045328302.1 type I secretion system permease/ATPase -
M5K26_RS17425 (M5K26_17400) 3641858..3643057 + 1200 WP_017382757.1 HlyD family efflux transporter periplasmic adaptor subunit -
M5K26_RS17430 (M5K26_17405) 3643308..3643607 + 300 WP_032654718.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5K26_RS17435 (M5K26_17410) 3643618..3643983 + 366 WP_015571639.1 HigA family addiction module antitoxin Antitoxin
M5K26_RS17440 (M5K26_17415) 3644010..3645191 - 1182 WP_017382758.1 PLP-dependent aminotransferase family protein -
M5K26_RS17445 (M5K26_17420) 3645212..3646099 - 888 WP_015571641.1 LysR family transcriptional regulator -
M5K26_RS17450 (M5K26_17425) 3646197..3646799 + 603 WP_017382759.1 short chain dehydrogenase -
M5K26_RS17455 (M5K26_17430) 3646910..3648289 - 1380 WP_045911566.1 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11582.25 Da        Isoelectric Point: 9.8425

>T245248 WP_032654718.1 NZ_CP097342:3643308-3643607 [Enterobacter hormaechei subsp. xiangfangensis]
MINHYRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNMYEALSPPLKGYSSIRVNRQYRLVFRW
SAGKADDLYLSPHKYTQHK

Download         Length: 300 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13705.73 Da        Isoelectric Point: 9.5936

>AT245248 WP_015571639.1 NZ_CP097342:3643618-3643983 [Enterobacter hormaechei subsp. xiangfangensis]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEMLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKSGKPDVTLHGNSA

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T9SGM4

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0PXC9

References