Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2986013..2986673 Replicon chromosome
Accession NZ_CP097342
Organism Enterobacter hormaechei subsp. xiangfangensis strain va18651

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag M5K26_RS14440 Protein ID WP_045910844.1
Coordinates 2986320..2986673 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2J0Q4Z7
Locus tag M5K26_RS14435 Protein ID WP_017383313.1
Coordinates 2986013..2986315 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5K26_RS14420 (M5K26_14400) 2982183..2983508 + 1326 WP_045910816.1 SidA/IucD/PvdA family monooxygenase -
M5K26_RS14425 (M5K26_14405) 2983535..2985724 + 2190 WP_023324924.1 TonB-dependent siderophore receptor -
M5K26_RS14435 (M5K26_14415) 2986013..2986315 - 303 WP_017383313.1 XRE family transcriptional regulator Antitoxin
M5K26_RS14440 (M5K26_14420) 2986320..2986673 - 354 WP_045910844.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5K26_RS14445 (M5K26_14425) 2986864..2987814 - 951 WP_003859532.1 HTH-type transcriptional regulator Cbl -
M5K26_RS14450 (M5K26_14430) 2987911..2988828 - 918 WP_003859531.1 nitrogen assimilation transcriptional regulator NAC -
M5K26_RS14460 (M5K26_14440) 2989319..2990242 - 924 WP_045910845.1 L,D-transpeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13557.40 Da        Isoelectric Point: 9.9193

>T245246 WP_045910844.1 NZ_CP097342:c2986673-2986320 [Enterobacter hormaechei subsp. xiangfangensis]
VWAIKTTDRFDDWFTSLNDSERASVLAALLVLREKGPGLSRPYADTLKGSRHSNMKELRIQSKGDPLRAFFAFDPNRTGI
VLCAGNKFGNERRFYDEMLLVADREYTRWLNTLKERN

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11028.85 Da        Isoelectric Point: 6.4727

>AT245246 WP_017383313.1 NZ_CP097342:c2986315-2986013 [Enterobacter hormaechei subsp. xiangfangensis]
MGRTLEQLIADEKPEVVASAQAMATDILLNIHLAELREKVQKTQVDMARALGIKQPTVAVMEKAGRDIKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0Q4Z7

References