Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1260888..1261615 Replicon chromosome
Accession NZ_CP097342
Organism Enterobacter hormaechei subsp. xiangfangensis strain va18651

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag M5K26_RS06115 Protein ID WP_045910678.1
Coordinates 1261304..1261615 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M5K26_RS06110 Protein ID WP_045910679.1
Coordinates 1260888..1261307 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5K26_RS06100 (M5K26_06100) 1258718..1259839 - 1122 WP_015571201.1 YbdK family carboxylate-amine ligase -
M5K26_RS06105 (M5K26_06105) 1259945..1260835 + 891 WP_045910680.1 oxidoreductase -
M5K26_RS06110 (M5K26_06110) 1260888..1261307 - 420 WP_045910679.1 helix-turn-helix domain-containing protein Antitoxin
M5K26_RS06115 (M5K26_06115) 1261304..1261615 - 312 WP_045910678.1 type II toxin-antitoxin system HigB family toxin Toxin
M5K26_RS06120 (M5K26_06120) 1261954..1262736 - 783 WP_045910677.1 DUF2971 domain-containing protein -
M5K26_RS06125 (M5K26_06125) 1262978..1263433 - 456 WP_045910676.1 hypothetical protein -
M5K26_RS06130 (M5K26_06130) 1263870..1264751 - 882 WP_003858850.1 LysR family transcriptional regulator -
M5K26_RS06135 (M5K26_06135) 1264857..1265636 + 780 WP_028012263.1 acetolactate decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-134)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12464.32 Da        Isoelectric Point: 10.0947

>T245240 WP_045910678.1 NZ_CP097342:c1261615-1261304 [Enterobacter hormaechei subsp. xiangfangensis]
MHIVSRAPFDTAARHYPNQAQALDDLYRVLKKEHYPSPGDMRKRFPSLDRMKYREKWWVIDVGGGHLRVMFFADFERGKI
FIKHISTHADYDKLMDYYRRTKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15389.48 Da        Isoelectric Point: 4.7238

>AT245240 WP_045910679.1 NZ_CP097342:c1261307-1260888 [Enterobacter hormaechei subsp. xiangfangensis]
MNYAAAIKAANALTNALPFLGSSPSRQDYEDALALVEYLIEHDPDNPLVEMLTAKIDKYENESPEFAEFNARIASIPSGV
ALLRTLMDQYQLTQSDFENEIGKKSLVSRILNGQRTLTLDHMRALAKRFGLPVSAFVGN

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References