Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 248236..248826 Replicon chromosome
Accession NZ_CP097341
Organism Alcaligenes faecalis strain DY-8

Toxin (Protein)


Gene name higB Uniprot ID A0A0A2N9E1
Locus tag M6D76_RS01110 Protein ID WP_035268575.1
Coordinates 248530..248826 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag M6D76_RS01105 Protein ID WP_042484646.1
Coordinates 248236..248523 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M6D76_RS01090 (M6D76_01090) 244023..245270 + 1248 WP_257112836.1 D-amino acid dehydrogenase -
M6D76_RS01095 (M6D76_01095) 245469..246479 - 1011 WP_060186540.1 acyltransferase family protein -
M6D76_RS01100 (M6D76_01100) 246758..248125 + 1368 WP_257112837.1 DNA recombination protein RmuC -
M6D76_RS01105 (M6D76_01105) 248236..248523 - 288 WP_042484646.1 HigA family addiction module antitoxin Antitoxin
M6D76_RS01110 (M6D76_01110) 248530..248826 - 297 WP_035268575.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M6D76_RS01115 (M6D76_01115) 248961..251525 - 2565 WP_257112838.1 EAL domain-containing protein -
M6D76_RS01120 (M6D76_01120) 251703..251981 + 279 WP_009460160.1 acylphosphatase -
M6D76_RS01125 (M6D76_01125) 252146..253039 + 894 WP_257112839.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-64)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11108.48 Da        Isoelectric Point: 9.3459

>T245238 WP_035268575.1 NZ_CP097341:c248826-248530 [Alcaligenes faecalis]
MIKSFRHKGLQAYFETGSKSGIQAKHAVRLQIQLTALHSATQAEDMNAPGWKLHKLSGKNPKGQSVQDHYTISVSGNWRL
TFYFEGEDAVLVDYQDYH

Download         Length: 297 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10430.96 Da        Isoelectric Point: 9.8929

>AT245238 WP_042484646.1 NZ_CP097341:c248523-248236 [Alcaligenes faecalis]
IMRMHNPSHPGPVLREYLGELSVTEAASRLGVTRAALSRILNGSAGISADMALRLRDALGTSAEMWINMQSHYDLWQAEQ
KPRPKVVSFHGPAHA

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A2N9E1

Antitoxin

Source ID Structure

References