Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1470435..1471078 Replicon chromosome
Accession NZ_CP097331
Organism Cupriavidus campinensis strain G5

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag M5D45_RS24365 Protein ID WP_144198245.1
Coordinates 1470435..1470734 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M5D45_RS24370 Protein ID WP_144198244.1
Coordinates 1470731..1471078 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5D45_RS24335 (M5D45_24335) 1465536..1465913 + 378 WP_246118965.1 RT0821/Lpp0805 family surface protein -
M5D45_RS24340 (M5D45_24340) 1465933..1466811 - 879 WP_250025426.1 mechanosensitive ion channel -
M5D45_RS24345 (M5D45_24345) 1466796..1467650 - 855 WP_250025427.1 cytochrome P450 -
M5D45_RS24350 (M5D45_24350) 1467747..1468223 - 477 WP_144198248.1 hypothetical protein -
M5D45_RS24355 (M5D45_24355) 1468292..1468924 - 633 WP_244844450.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
M5D45_RS24360 (M5D45_24360) 1469367..1470257 - 891 WP_144198246.1 helix-turn-helix domain-containing protein -
M5D45_RS24365 (M5D45_24365) 1470435..1470734 + 300 WP_144198245.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5D45_RS24370 (M5D45_24370) 1470731..1471078 + 348 WP_144198244.1 HigA family addiction module antitoxin Antitoxin
M5D45_RS24375 (M5D45_24375) 1471221..1472533 + 1313 Protein_1308 hemolysin family protein -
M5D45_RS24380 (M5D45_24380) 1472909..1474231 + 1323 WP_144198242.1 bifunctional diguanylate cyclase/phosphodiesterase -
M5D45_RS24385 (M5D45_24385) 1474412..1474528 + 117 WP_244844451.1 entericidin A/B family lipoprotein -
M5D45_RS24390 (M5D45_24390) 1474654..1475295 - 642 WP_144198241.1 bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(28-86)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11280.89 Da        Isoelectric Point: 10.4170

>T245174 WP_144198245.1 NZ_CP097331:1470435-1470734 [Cupriavidus campinensis]
MIRTFANKATAAVFCGRYVSTLPRHIQATAFRKLGLLDAAASLTDMQAPPANRLEALRGVRRGQWSIQIHNQWRICFRFQ
NGEAWDVDIADYHRQPEPA

Download         Length: 300 bp

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 12723.57 Da        Isoelectric Point: 7.2047

>AT245174 WP_144198244.1 NZ_CP097331:1470731-1471078 [Cupriavidus campinensis]
MTIKREDLPRLDASDVETGEPLAPVHPGEILRQDFMAPHGLSANALAIALRVPAPRINDVVRGRRAISPETALRLARYFG
TTPQFWANLQAGYDLRIAQEKAGEKIDREIQPLTA

Download         Length: 348 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References