Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 899100..899682 Replicon chromosome
Accession NZ_CP097330
Organism Cupriavidus campinensis strain G5

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag M5D45_RS04150 Protein ID WP_144201665.1
Coordinates 899100..899378 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M5D45_RS04155 Protein ID WP_144201663.1
Coordinates 899392..899682 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5D45_RS04130 (M5D45_04130) 894700..895293 + 594 WP_144201671.1 DUF1415 domain-containing protein -
M5D45_RS04135 (M5D45_04135) 895348..896190 - 843 WP_144201669.1 SAM-dependent methyltransferase -
M5D45_RS04140 (M5D45_04140) 896452..898065 + 1614 WP_144201667.1 FapA family protein -
M5D45_RS04145 (M5D45_04145) 898255..898701 + 447 WP_186296952.1 response regulator transcription factor -
M5D45_RS04150 (M5D45_04150) 899100..899378 + 279 WP_144201665.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5D45_RS04155 (M5D45_04155) 899392..899682 + 291 WP_144201663.1 HigA family addiction module antitoxin Antitoxin
M5D45_RS04160 (M5D45_04160) 899985..901385 + 1401 WP_250025113.1 site-specific integrase -
M5D45_RS04165 (M5D45_04165) 901416..901757 - 342 WP_250025114.1 hypothetical protein -
M5D45_RS04170 (M5D45_04170) 902468..902929 - 462 WP_250025115.1 hypothetical protein -
M5D45_RS04175 (M5D45_04175) 903020..903235 - 216 WP_250025116.1 hypothetical protein -
M5D45_RS04180 (M5D45_04180) 903718..904140 + 423 WP_250025117.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 899100..929480 30380


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10419.99 Da        Isoelectric Point: 9.8292

>T245171 WP_144201665.1 NZ_CP097330:899100-899378 [Cupriavidus campinensis]
MIRSFAHKGLERFFTTGSTAAIPAMHVKRLRLILALLDEAGSARDMDAPGLRLHALKGDRAELWAVTVQANWRVTFRFEN
GDAHIVNYIDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10779.31 Da        Isoelectric Point: 6.2194

>AT245171 WP_144201663.1 NZ_CP097330:899392-899682 [Cupriavidus campinensis]
MRMHNPPHPGELLAELWLEPLRLTITDTAAALDVSRKTVSEIVNGRAGVTPEMAVRLELAFGKSAESWLAHQAAYDLWQV
DQYRSELRVRSLQPAT

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References