245128

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1839874..1840474 Replicon chromosome
Accession NZ_CP097320
Organism Candidatus Mycobacterium methanotrophicum isolate Sulfur Cave

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag M5I08_RS09880 Protein ID WP_219066447.1
Coordinates 1839874..1840155 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag M5I08_RS09885 Protein ID WP_219066448.1
Coordinates 1840187..1840474 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5I08_RS09860 (M5I08_09860) 1835760..1836446 - 687 WP_219066443.1 MBL fold metallo-hydrolase -
M5I08_RS09865 (M5I08_09865) 1836817..1837521 + 705 WP_219066444.1 hypothetical protein -
M5I08_RS26165 1837612..1837743 + 132 WP_255564668.1 hypothetical protein -
M5I08_RS09870 (M5I08_09870) 1837830..1839101 - 1272 WP_219066445.1 RNA-guided endonuclease TnpB family protein -
M5I08_RS09875 (M5I08_09875) 1839331..1839774 + 444 WP_249763226.1 hypothetical protein -
M5I08_RS09880 (M5I08_09880) 1839874..1840155 + 282 WP_219066447.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5I08_RS09885 (M5I08_09885) 1840187..1840474 + 288 WP_219066448.1 HigA family addiction module antitoxin Antitoxin
M5I08_RS09890 (M5I08_09890) 1840491..1841894 - 1404 WP_249763337.1 DNA methyltransferase -
M5I08_RS09895 (M5I08_09895) 1842062..1843462 + 1401 WP_219066449.1 IS1380 family transposase -
M5I08_RS09900 (M5I08_09900) 1844066..1844425 - 360 Protein_1963 site-specific DNA-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-64)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10690.11 Da        Isoelectric Point: 9.5446

>T245128 WP_219066447.1 NZ_CP097320:1839874-1840155 [Candidatus Mycobacterium methanotrophicum]
VIRSFRAKDTEAIWQRRYVKELSPELSRLTYNKLVLINAAESINDLRVPPGNRPEKPSGIRAGQYSVRVNDQWRLCFTWS
TAGAGDVELVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10533.19 Da        Isoelectric Point: 6.7232

>AT245128 WP_219066448.1 NZ_CP097320:1840187-1840474 [Candidatus Mycobacterium methanotrophicum]
MADFAPTHPGEILLTEFLAPMGISQYRVAKVIDVPPRRINEIVHGKRGISADTALRLSRALGLTDMFFINMQAHYDAEIA
REQLANTLASIDRIA

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References