Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 106009..106601 Replicon plasmid pPROV188-1
Accession NZ_CP097292
Organism Providencia sp. PROV188

Toxin (Protein)


Gene name higB Uniprot ID A0A6L6F789
Locus tag M5X66_RS18320 Protein ID WP_036954335.1
Coordinates 106323..106601 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M5X66_RS18315 Protein ID WP_036954329.1
Coordinates 106009..106323 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5X66_RS18305 (M5X66_18300) 103671..105047 - 1377 WP_036954325.1 conjugal transfer pilus assembly protein TraH -
M5X66_RS18310 (M5X66_18305) 105459..105811 + 353 Protein_77 transposase -
M5X66_RS18315 (M5X66_18310) 106009..106323 - 315 WP_036954329.1 HigA family addiction module antitoxin Antitoxin
M5X66_RS18320 (M5X66_18315) 106323..106601 - 279 WP_036954335.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5X66_RS18325 (M5X66_18320) 106645..107217 - 573 WP_282561917.1 type-F conjugative transfer system pilin assembly thiol-disulfide isomerase TrbB -
M5X66_RS18330 (M5X66_18325) 107196..107516 - 321 WP_282561919.1 hypothetical protein -
M5X66_RS18335 (M5X66_18330) 107527..108312 - 786 WP_036954346.1 type-F conjugative transfer system pilin assembly protein TraF -
M5X66_RS18340 (M5X66_18335) 108258..110153 - 1896 WP_282561920.1 conjugal transfer protein TraN -
M5X66_RS18345 (M5X66_18340) 110135..110884 - 750 WP_282561921.1 type-F conjugative transfer system pilin assembly protein TrbC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - prgK / prgI / sicA / spaS / spaQ / spaP / invC/sctN / invA / cdtA / cdtC 1..145399 145399


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10857.23 Da        Isoelectric Point: 8.4391

>T245113 WP_036954335.1 NZ_CP097292:c106601-106323 [Providencia sp. PROV188]
MIKSFKHKGLKQLFEKGNTSGVPAQDAERINDRLQAIDTANDIRELDRQIYKLHPLKGDREGYWSITVRANWRITFQFIN
GDAYILNYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11415.05 Da        Isoelectric Point: 7.2028

>AT245113 WP_036954329.1 NZ_CP097292:c106323-106009 [Providencia sp. PROV188]
MRQFKISHPGEIIARDLADMGISGRRFALNIGVTPATVSRFLSGKTALTPALAIRIAAALGSTPEFWLRLQSAYDLRQLE
NKIDTSDIILYEEPSDSSEGISKH

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L6F789

Antitoxin

Source ID Structure

References