Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 3826476..3826983 Replicon chromosome
Accession NZ_CP097291
Organism Providencia sp. PROV188

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag M5X66_RS17670 Protein ID WP_036950778.1
Coordinates 3826723..3826983 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A4R3NGF7
Locus tag M5X66_RS17665 Protein ID WP_006663215.1
Coordinates 3826476..3826730 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5X66_RS17645 (M5X66_17645) 3822036..3823184 + 1149 WP_036950785.1 polysaccharide export protein -
M5X66_RS17650 (M5X66_17650) 3823207..3823635 + 429 WP_154610082.1 protein tyrosine phosphatase -
M5X66_RS17655 (M5X66_17655) 3823668..3825749 + 2082 WP_270103773.1 polysaccharide biosynthesis tyrosine autokinase -
M5X66_RS17660 (M5X66_17660) 3825869..3826372 + 504 WP_036950780.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
M5X66_RS17665 (M5X66_17665) 3826476..3826730 + 255 WP_006663215.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
M5X66_RS17670 (M5X66_17670) 3826723..3826983 + 261 WP_036950778.1 Txe/YoeB family addiction module toxin Toxin
M5X66_RS17675 (M5X66_17675) 3826990..3827811 - 822 WP_036950776.1 serine O-acetyltransferase -
M5X66_RS17680 (M5X66_17680) 3827835..3828863 - 1029 WP_108479153.1 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase -
M5X66_RS17685 (M5X66_17685) 3828873..3829340 - 468 WP_006660561.1 protein-export chaperone SecB -
M5X66_RS17690 (M5X66_17690) 3829414..3829848 - 435 WP_230085095.1 rhodanese-like domain-containing protein -
M5X66_RS17695 (M5X66_17695) 3830267..3831559 + 1293 WP_036950769.1 murein hydrolase activator EnvC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10322.84 Da        Isoelectric Point: 9.4082

>T245112 WP_036950778.1 NZ_CP097291:3826723-3826983 [Providencia sp. PROV188]
MSRLLTWTDQAWEDYLYWQSQDKKTLKRINKLIEDTKRTPFSGIGKPEPLKENLAGFWSRRIDETNRLVYAIENTALIII
ACRYHY

Download         Length: 261 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9596.97 Da        Isoelectric Point: 5.8373

>AT245112 WP_006663215.1 NZ_CP097291:3826476-3826730 [Providencia sp. PROV188]
MKTISFSDARSNLKAVLDRVVDDMDTTIITRRDSEAAVVMSLEYYNSLMETIYLLRSPANAEHLNKSIEQFKAGKISERK
LINE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4R3NGF7

References