Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 5224544..5225052 Replicon chromosome
Accession NZ_CP097289
Organism Streptomyces durmitorensis strain MS405

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag M4V62_RS23510 Protein ID WP_160505759.1
Coordinates 5224544..5224804 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag M4V62_RS23515 Protein ID WP_160505758.1
Coordinates 5224801..5225052 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4V62_RS23490 (M4V62_23490) 5220029..5220304 + 276 WP_249589202.1 MoaD/ThiS family protein -
M4V62_RS23495 (M4V62_23495) 5220729..5220932 + 204 WP_005315736.1 cold-shock protein -
M4V62_RS23500 (M4V62_23500) 5221221..5222846 + 1626 WP_160505762.1 chaperonin GroEL -
M4V62_RS23505 (M4V62_23505) 5222959..5224182 - 1224 WP_249589203.1 alpha/beta hydrolase -
M4V62_RS23510 (M4V62_23510) 5224544..5224804 - 261 WP_160505759.1 Txe/YoeB family addiction module toxin Toxin
M4V62_RS23515 (M4V62_23515) 5224801..5225052 - 252 WP_160505758.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
M4V62_RS23520 (M4V62_23520) 5225130..5225942 - 813 WP_249592951.1 hypothetical protein -
M4V62_RS23525 (M4V62_23525) 5226233..5226499 - 267 WP_249589204.1 DUF397 domain-containing protein -
M4V62_RS23530 (M4V62_23530) 5226480..5227322 - 843 WP_249589205.1 helix-turn-helix transcriptional regulator -
M4V62_RS23535 (M4V62_23535) 5227439..5227651 + 213 WP_249589206.1 hypothetical protein -
M4V62_RS23540 (M4V62_23540) 5227869..5228123 + 255 WP_249589207.1 type II toxin-antitoxin system VapB family antitoxin -
M4V62_RS23545 (M4V62_23545) 5228120..5228545 + 426 WP_249592952.1 PIN domain-containing protein -
M4V62_RS23550 (M4V62_23550) 5228580..5229335 - 756 WP_249589208.1 polysaccharide deacetylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10636.04 Da        Isoelectric Point: 8.8806

>T245104 WP_160505759.1 NZ_CP097289:c5224804-5224544 [Streptomyces durmitorensis]
MKFVWDESPWQDYVWWQTQDRRVLKRINTLLQDIARNGNEGIGKPEPLKHGFQGYWSRRITDEHRLIYKIVEDEIRIASC
RYHYER

Download         Length: 261 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9388.55 Da        Isoelectric Point: 4.5576

>AT245104 WP_160505758.1 NZ_CP097289:c5225052-5224801 [Streptomyces durmitorensis]
MRTMTYTESRAKYAETLNAVTDDREEVIVTRAGREPVVIVALEEYESLKETAYLLRNPENARRLLASIDRLESGGGTVRE
LAE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References