Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4488509..4489111 Replicon chromosome
Accession NZ_CP097262
Organism Salmonella enterica subsp. enterica strain B3-6

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag M3N94_RS21785 Protein ID WP_001159635.1
Coordinates 4488800..4489111 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M3N94_RS21780 Protein ID WP_000362050.1
Coordinates 4488509..4488799 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3N94_RS21765 (4486002) 4486002..4486904 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
M3N94_RS21770 (4486901) 4486901..4487536 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
M3N94_RS21775 (4487533) 4487533..4488462 + 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
M3N94_RS21780 (4488509) 4488509..4488799 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
M3N94_RS21785 (4488800) 4488800..4489111 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
M3N94_RS21790 (4489329) 4489329..4490258 + 930 WP_001127705.1 alpha/beta hydrolase -
M3N94_RS21795 (4490344) 4490344..4490655 + 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin -
M3N94_RS21800 (4490652) 4490652..4491098 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
M3N94_RS21805 (4491113) 4491113..4492054 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
M3N94_RS21810 (4492099) 4492099..4492536 - 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
M3N94_RS21815 (4492533) 4492533..4493405 - 873 WP_000921423.1 virulence factor BrkB family protein -
M3N94_RS21820 (4493399) 4493399..4493998 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T245089 WP_001159635.1 NZ_CP097262:c4489111-4488800 [Salmonella enterica subsp. enterica]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT245089 WP_000362050.1 NZ_CP097262:c4488799-4488509 [Salmonella enterica subsp. enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References