Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 3183424..3184151 | Replicon | chromosome |
| Accession | NC_013716 | ||
| Organism | Citrobacter rodentium ICC168 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | D2TKI0 |
| Locus tag | ROD_RS14865 | Protein ID | WP_012907141.1 |
| Coordinates | 3183840..3184151 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | ROD_RS14860 | Protein ID | WP_012907140.1 |
| Coordinates | 3183424..3183843 (-) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ROD_RS26500 | 3178700..3179299 | - | 600 | WP_012907136.1 | hypothetical protein | - |
| ROD_RS14830 | 3179296..3179610 | - | 315 | WP_024132853.1 | type III secretion system filament chaperone | - |
| ROD_RS14835 | 3179616..3179834 | - | 219 | WP_012907138.1 | EscE/YscE/SsaE family type III secretion system needle protein co-chaperone | - |
| ROD_RS14840 | 3179849..3180220 | - | 372 | WP_024132854.1 | H-NS histone family protein | - |
| ROD_RS14845 | 3180574..3182145 | - | 1572 | WP_012904571.1 | IS66-like element ISCro1 family transposase | - |
| ROD_RS14850 | 3182165..3182512 | - | 348 | WP_012904570.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| ROD_RS14855 | 3182512..3183189 | - | 678 | WP_012904569.1 | IS66 family insertion sequence hypothetical protein | - |
| ROD_RS14860 | 3183424..3183843 | - | 420 | WP_012907140.1 | helix-turn-helix domain-containing protein | Antitoxin |
| ROD_RS14865 | 3183840..3184151 | - | 312 | WP_012907141.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| ROD_RS14870 | 3184380..3184709 | + | 330 | WP_012907142.1 | YqcC family protein | - |
| ROD_RS14875 | 3184709..3185491 | + | 783 | Protein_2947 | tRNA pseudouridine(65) synthase TruC | - |
| ROD_RS14880 | 3185509..3185958 | + | 450 | WP_012907143.1 | flavodoxin | - |
| ROD_RS14885 | 3186442..3187794 | + | 1353 | WP_012907145.1 | galactarate/glucarate/glycerate transporter GudP | - |
| ROD_RS14890 | 3187797..3189137 | + | 1341 | WP_012907146.1 | glucarate dehydratase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12320.07 Da Isoelectric Point: 9.7853
>T24508 WP_012907141.1 NC_013716:c3184151-3183840 [Citrobacter rodentium ICC168]
VHIISKEPFEQAARLFPNDAMAIRALYRLVSETDFKSPDELRTAVPSLDNFKYRNKWWVLDVGGHNLRVIAYINFVNKRF
YVKHIATHAEYDKLTRYYRENKE
VHIISKEPFEQAARLFPNDAMAIRALYRLVSETDFKSPDELRTAVPSLDNFKYRNKWWVLDVGGHNLRVIAYINFVNKRF
YVKHIATHAEYDKLTRYYRENKE
Download Length: 312 bp
>T24508 NC_013716:c3184151-3183840 [Citrobacter rodentium ICC168]
GTGCACATCATCTCCAAAGAGCCATTTGAGCAAGCGGCGCGGTTATTTCCAAACGACGCCATGGCCATTAGGGCGCTGTA
TCGCCTGGTAAGCGAAACAGACTTCAAATCGCCCGATGAGTTGCGCACCGCCGTGCCGAGTCTCGACAATTTTAAGTACC
GGAACAAATGGTGGGTTTTAGATGTGGGTGGTCATAATTTGCGAGTTATCGCCTACATCAACTTTGTGAATAAACGCTTC
TACGTGAAGCACATCGCCACCCACGCTGAATACGATAAGCTGACTCGCTACTATCGGGAGAACAAAGAATGA
GTGCACATCATCTCCAAAGAGCCATTTGAGCAAGCGGCGCGGTTATTTCCAAACGACGCCATGGCCATTAGGGCGCTGTA
TCGCCTGGTAAGCGAAACAGACTTCAAATCGCCCGATGAGTTGCGCACCGCCGTGCCGAGTCTCGACAATTTTAAGTACC
GGAACAAATGGTGGGTTTTAGATGTGGGTGGTCATAATTTGCGAGTTATCGCCTACATCAACTTTGTGAATAAACGCTTC
TACGTGAAGCACATCGCCACCCACGCTGAATACGATAAGCTGACTCGCTACTATCGGGAGAACAAAGAATGA
Antitoxin
Download Length: 140 a.a. Molecular weight: 15518.62 Da Isoelectric Point: 4.5455
>AT24508 WP_012907140.1 NC_013716:c3183843-3183424 [Citrobacter rodentium ICC168]
MIADTTKAIEATKQLVAAVPLLGGSTSEKDYRDALELVEYLIDHDDENPLIDFLAAKIADYEDNSEQFAEFNKRIAEIPV
GVALLRTLIDQHQLSYSDLKNEIGSKSLVSQILSGQRSLTISHIKALSERFGIKPQWFL
MIADTTKAIEATKQLVAAVPLLGGSTSEKDYRDALELVEYLIDHDDENPLIDFLAAKIADYEDNSEQFAEFNKRIAEIPV
GVALLRTLIDQHQLSYSDLKNEIGSKSLVSQILSGQRSLTISHIKALSERFGIKPQWFL
Download Length: 420 bp
>AT24508 NC_013716:c3183843-3183424 [Citrobacter rodentium ICC168]
ATGATCGCCGACACCACTAAAGCTATCGAAGCAACGAAGCAACTGGTAGCTGCCGTCCCTCTGCTGGGGGGCAGCACCTC
AGAGAAAGACTACCGCGACGCGCTGGAGCTGGTGGAGTACCTGATCGACCACGACGACGAGAACCCGCTGATCGACTTCC
TGGCAGCCAAGATTGCGGATTACGAGGACAACAGCGAACAGTTTGCGGAGTTCAACAAACGCATTGCAGAGATTCCGGTT
GGCGTCGCGCTACTGCGCACCCTGATTGACCAGCATCAGCTCTCCTACTCCGACCTGAAGAATGAGATTGGATCCAAATC
GCTGGTGAGCCAGATCCTTTCCGGCCAGCGCTCCCTGACGATCTCACACATCAAGGCGCTTTCGGAGCGGTTCGGCATCA
AGCCGCAGTGGTTTCTCTGA
ATGATCGCCGACACCACTAAAGCTATCGAAGCAACGAAGCAACTGGTAGCTGCCGTCCCTCTGCTGGGGGGCAGCACCTC
AGAGAAAGACTACCGCGACGCGCTGGAGCTGGTGGAGTACCTGATCGACCACGACGACGAGAACCCGCTGATCGACTTCC
TGGCAGCCAAGATTGCGGATTACGAGGACAACAGCGAACAGTTTGCGGAGTTCAACAAACGCATTGCAGAGATTCCGGTT
GGCGTCGCGCTACTGCGCACCCTGATTGACCAGCATCAGCTCTCCTACTCCGACCTGAAGAATGAGATTGGATCCAAATC
GCTGGTGAGCCAGATCCTTTCCGGCCAGCGCTCCCTGACGATCTCACACATCAAGGCGCTTTCGGAGCGGTTCGGCATCA
AGCCGCAGTGGTTTCTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|