245064

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5302439..5303034 Replicon chromosome
Accession NZ_CP097256
Organism Pseudomonas aeruginosa strain D5

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag M4954_RS24650 Protein ID WP_003117425.1
Coordinates 5302756..5303034 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M4954_RS24645 Protein ID WP_003099268.1
Coordinates 5302439..5302744 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4954_RS24625 (M4954_24625) 5297948..5299498 - 1551 WP_071535171.1 AAA family ATPase -
M4954_RS24630 (M4954_24630) 5299521..5299919 - 399 WP_051428818.1 ASCH domain-containing protein -
M4954_RS24635 (M4954_24635) 5299897..5300949 - 1053 WP_051428817.1 hypothetical protein -
M4954_RS24640 (M4954_24640) 5300953..5301483 - 531 WP_071535170.1 ATP-binding protein -
M4954_RS24645 (M4954_24645) 5302439..5302744 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
M4954_RS24650 (M4954_24650) 5302756..5303034 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M4954_RS24655 (M4954_24655) 5303087..5303215 - 129 Protein_4877 integrase -
M4954_RS24660 (M4954_24660) 5303363..5305591 + 2229 WP_003099265.1 TonB-dependent receptor -
M4954_RS24665 (M4954_24665) 5305661..5306308 - 648 WP_003095021.1 carbonate dehydratase -
M4954_RS24670 (M4954_24670) 5306370..5307608 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T245064 WP_003117425.1 NZ_CP097256:c5303034-5302756 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT245064 WP_003099268.1 NZ_CP097256:c5302744-5302439 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References