245063

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4660962..4661643 Replicon chromosome
Accession NZ_CP097256
Organism Pseudomonas aeruginosa strain D5

Toxin (Protein)


Gene name higB Uniprot ID V6AKP0
Locus tag M4954_RS21665 Protein ID WP_003111825.1
Coordinates 4661278..4661643 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M4954_RS21660 Protein ID WP_003145733.1
Coordinates 4660962..4661285 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4954_RS21635 (M4954_21635) 4656875..4657513 + 639 WP_003109444.1 hypothetical protein -
M4954_RS21640 (M4954_21640) 4657756..4658091 + 336 WP_003140884.1 TM2 domain-containing protein -
M4954_RS21645 (M4954_21645) 4658265..4658783 + 519 WP_022579807.1 PAAR domain-containing protein -
M4954_RS21650 (M4954_21650) 4658780..4659481 + 702 WP_003111822.1 VRR-NUC domain-containing protein -
M4954_RS21655 (M4954_21655) 4659498..4660586 + 1089 WP_034025227.1 DUF3396 domain-containing protein -
M4954_RS21660 (M4954_21660) 4660962..4661285 - 324 WP_003145733.1 XRE family transcriptional regulator Antitoxin
M4954_RS21665 (M4954_21665) 4661278..4661643 - 366 WP_003111825.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M4954_RS21670 (M4954_21670) 4661907..4662146 - 240 WP_049876884.1 hypothetical protein -
M4954_RS21675 (M4954_21675) 4662353..4662625 + 273 WP_003085667.1 hypothetical protein -
M4954_RS21680 (M4954_21680) 4662644..4663069 - 426 WP_003114206.1 VOC family protein -
M4954_RS21685 (M4954_21685) 4663170..4664054 + 885 WP_003114205.1 LysR family transcriptional regulator -
M4954_RS21690 (M4954_21690) 4664027..4664980 - 954 WP_003085661.1 LysR substrate-binding domain-containing protein -
M4954_RS21695 (M4954_21695) 4665201..4665635 + 435 WP_010793869.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13880.24 Da        Isoelectric Point: 4.8219

>T245063 WP_003111825.1 NZ_CP097256:c4661643-4661278 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRHGHMRELRTQHGGRPFRTLYAFDPRRSA
ILLIGGDKTGDDRWYELNVPIADRLYDEHLHQLREEGLIDG

Download         Length: 366 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11896.73 Da        Isoelectric Point: 6.4751

>AT245063 WP_003145733.1 NZ_CP097256:c4661285-4660962 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEAQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLHVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AKP0

Antitoxin

Source ID Structure

References