Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4538671..4539273 Replicon chromosome
Accession NZ_CP097255
Organism Enterobacter bugandensis strain CMCC(B)45301

Toxin (Protein)


Gene name higB Uniprot ID A0A167J774
Locus tag M1V99_RS22080 Protein ID WP_047366784.1
Coordinates 4538962..4539273 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M1V99_RS22075 Protein ID WP_194386695.1
Coordinates 4538671..4538961 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1V99_RS22060 (M1V99_22060) 4536169..4537071 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
M1V99_RS22065 (M1V99_22065) 4537068..4537703 + 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
M1V99_RS22070 (M1V99_22070) 4537700..4538629 + 930 WP_028014872.1 formate dehydrogenase accessory protein FdhE -
M1V99_RS22075 (M1V99_22075) 4538671..4538961 - 291 WP_194386695.1 NadS family protein Antitoxin
M1V99_RS22080 (M1V99_22080) 4538962..4539273 - 312 WP_047366784.1 hypothetical protein Toxin
M1V99_RS22085 (M1V99_22085) 4539422..4540363 - 942 WP_047366783.1 fatty acid biosynthesis protein FabY -
M1V99_RS22090 (M1V99_22090) 4540408..4540845 - 438 WP_008501836.1 D-aminoacyl-tRNA deacylase -
M1V99_RS22095 (M1V99_22095) 4540842..4541723 - 882 WP_045260235.1 virulence factor BrkB family protein -
M1V99_RS22100 (M1V99_22100) 4541717..4542316 - 600 WP_045260234.1 glucose-1-phosphatase -
M1V99_RS22105 (M1V99_22105) 4542404..4542874 - 471 WP_028014878.1 hypothetical protein -
M1V99_RS22110 (M1V99_22110) 4542871..4543614 - 744 WP_194386694.1 winged helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12135.13 Da        Isoelectric Point: 8.8415

>T245058 WP_047366784.1 NZ_CP097255:c4539273-4538962 [Enterobacter bugandensis]
MLFIETDIFTEDVKTLLDDDEYHRFQIFLATQPEYGDVIQNTGGLRKIRWLAGGKGKRGGVRVIYFYRTCEFEIRLLLIY
RKGIKDDLSAGEKAILKKMIERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10702.23 Da        Isoelectric Point: 10.7342

>AT245058 WP_194386695.1 NZ_CP097255:c4538961-4538671 [Enterobacter bugandensis]
MDKALFERLTQSVGQMNEIAEGQREPSRIFQIDAMRIKEIRQASGLSQSKFATLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVIPALSQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A167J774

Antitoxin

Source ID Structure

References