Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3573177..3573834 Replicon chromosome
Accession NZ_CP097255
Organism Enterobacter bugandensis strain CMCC(B)45301

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag M1V99_RS17380 Protein ID WP_048957972.1
Coordinates 3573177..3573476 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M1V99_RS17385 Protein ID WP_047367527.1
Coordinates 3573487..3573834 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1V99_RS17355 (M1V99_17355) 3569437..3569622 + 186 WP_249488143.1 hypothetical protein -
M1V99_RS17360 (M1V99_17360) 3569647..3570069 + 423 WP_249488144.1 hypothetical protein -
M1V99_RS17365 (M1V99_17365) 3570083..3570481 + 399 WP_249488145.1 hypothetical protein -
M1V99_RS17370 (M1V99_17370) 3570575..3571669 + 1095 WP_249488146.1 ATP-binding cassette domain-containing protein -
M1V99_RS17375 (M1V99_17375) 3571666..3572873 + 1208 Protein_3297 HlyD family efflux transporter periplasmic adaptor subunit -
M1V99_RS17380 (M1V99_17380) 3573177..3573476 + 300 WP_048957972.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M1V99_RS17385 (M1V99_17385) 3573487..3573834 + 348 WP_047367527.1 HigA family addiction module antitoxin Antitoxin
M1V99_RS17390 (M1V99_17390) 3573836..3574567 - 732 WP_048998571.1 helix-turn-helix transcriptional regulator -
M1V99_RS17395 (M1V99_17395) 3574747..3575088 + 342 WP_249488147.1 nuclear transport factor 2 family protein -
M1V99_RS17400 (M1V99_17400) 3575134..3576315 - 1182 WP_047367525.1 PLP-dependent aminotransferase family protein -
M1V99_RS17405 (M1V99_17405) 3576336..3577223 - 888 WP_045260881.1 LysR family transcriptional regulator -
M1V99_RS17410 (M1V99_17410) 3577321..3577923 + 603 WP_249488148.1 short chain dehydrogenase -
M1V99_RS17415 (M1V99_17415) 3577917..3578651 - 735 WP_249488149.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-102)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11538.15 Da        Isoelectric Point: 10.0104

>T245056 WP_048957972.1 NZ_CP097255:3573177-3573476 [Enterobacter bugandensis]
MINHFRDQWLKDFFLYGKSSNVIPSSLESALARKLDMINAATSHRELRSPPGNMYESLNPPLAGYSAIRVNRQYRLVFRW
SEGKADDLYLSPHKYTPYK

Download         Length: 300 bp

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13126.08 Da        Isoelectric Point: 7.0141

>AT245056 WP_047367527.1 NZ_CP097255:3573487-3573834 [Enterobacter bugandensis]
MTLQQALRKPTTPGDVLQYEYLEPLNLKISDLAEMLNVHRNTISALVNNNRKLTADMAIRLAKAFDTTIEFWLNLQLNVD
VWEAQTNSRTQEELSRIKTIAEIMAKRKSGQPDVA

Download         Length: 348 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References