Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 11796..12655 Replicon plasmid pCMCCB45301
Accession NZ_CP097254
Organism Enterobacter bugandensis strain CMCC(B)45301

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag M1V99_RS00065 Protein ID WP_108376731.1
Coordinates 11796..12290 (-) Length 165 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag M1V99_RS00070 Protein ID WP_108376736.1
Coordinates 12311..12655 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1V99_RS00040 (M1V99_00045) 7639..7878 + 240 WP_230041377.1 hypothetical protein -
M1V99_RS00045 (M1V99_00050) 8300..9058 - 759 WP_249488039.1 hypothetical protein -
M1V99_RS00050 (M1V99_00055) 9221..10069 - 849 WP_108376733.1 DUF4942 domain-containing protein -
M1V99_RS00055 (M1V99_00060) 10261..10941 - 681 WP_249488040.1 hypothetical protein -
M1V99_RS00060 (M1V99_00065) 11038..11286 - 249 WP_223239720.1 hypothetical protein -
M1V99_RS00065 (M1V99_00070) 11796..12290 - 495 WP_108376731.1 type II toxin-antitoxin system YhaV family toxin Toxin
M1V99_RS00070 (M1V99_00075) 12311..12655 - 345 WP_108376736.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
M1V99_RS00075 (M1V99_00080) 12987..13205 - 219 WP_188246026.1 type II toxin-antitoxin system VapB family antitoxin -
M1V99_RS00080 (M1V99_00085) 13445..13675 - 231 WP_188246027.1 hypothetical protein -
M1V99_RS00085 (M1V99_00090) 13666..13929 - 264 WP_188246028.1 DUF1380 family protein -
M1V99_RS00090 (M1V99_00095) 14036..14317 - 282 WP_188246032.1 hypothetical protein -
M1V99_RS00095 (M1V99_00100) 14466..14984 - 519 WP_188246029.1 hypothetical protein -
M1V99_RS00100 (M1V99_00105) 14974..15348 - 375 WP_249488041.1 hypothetical protein -
M1V99_RS00105 (M1V99_00110) 15360..15629 - 270 WP_249488042.1 hypothetical protein -
M1V99_RS00110 (M1V99_00115) 15736..16167 - 432 WP_188246031.1 antirestriction protein -
M1V99_RS00115 (M1V99_00120) 16483..16713 + 231 WP_249488043.1 hypothetical protein -
M1V99_RS00120 (M1V99_00125) 16987..17424 - 438 WP_188246038.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..81691 81691


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(11-147)

Antitoxin

PrlF antitoxin

(16-114)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 19174.06 Da        Isoelectric Point: 8.6417

>T245048 WP_108376731.1 NZ_CP097254:c12290-11796 [Enterobacter bugandensis]
MEYLELNGWKICFHKCFLDQIAELAQKVAELKAAKPNEYHKKKETKLLLAIERVIEEWIASDPLNPQYRQGDTLGDEYKH
WFRVKFLQQFRLFYRCSQEHKTIIIGWVNDFDTLRAYGSKTDAYKVFAEMLKAGTPPDDWNTLLNAAKKATATNTIPGFL
TRQP

Download         Length: 495 bp

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12595.34 Da        Isoelectric Point: 4.5594

>AT245048 WP_108376736.1 NZ_CP097254:c12655-12311 [Enterobacter bugandensis]
MATQIFHNADVSLRAESRLTERSQTTIPAAIRDALHLKPGESIHYTLLAGGKVIMSKKEEEQDDPVIPQFLAFLENDMKK
NPQNIAPVPALFWESIKALTAGVEVDLDAPLTDD

Download         Length: 345 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References