245038

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2583979..2584574 Replicon chromosome
Accession NZ_CP097252
Organism Mesorhizobium opportunistum strain WSM1558

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag M5D98_RS12475 Protein ID WP_224687692.1
Coordinates 2584293..2584574 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M5D98_RS12470 Protein ID WP_023779626.1
Coordinates 2583979..2584278 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5D98_RS12425 (M5D98_12425) 2579012..2579149 - 138 WP_023768804.1 hypothetical protein -
M5D98_RS12430 (M5D98_12430) 2579194..2579460 - 267 WP_013893514.1 hypothetical protein -
M5D98_RS12435 (M5D98_12435) 2579457..2579726 - 270 WP_224687696.1 hypothetical protein -
M5D98_RS12440 (M5D98_12440) 2579913..2580119 - 207 WP_224687695.1 cold-shock protein -
M5D98_RS12445 (M5D98_12445) 2580448..2580672 + 225 WP_140571906.1 hypothetical protein -
M5D98_RS12450 (M5D98_12450) 2580857..2582494 + 1638 WP_224687694.1 tetratricopeptide repeat-containing sulfotransferase family protein -
M5D98_RS12455 (M5D98_12455) 2582530..2582883 - 354 WP_023768800.1 DUF1428 domain-containing protein -
M5D98_RS12460 (M5D98_12460) 2583081..2583503 - 423 WP_224687693.1 glyoxalase/bleomycin resistance/extradiol dioxygenase family protein -
M5D98_RS12465 (M5D98_12465) 2583663..2583845 - 183 WP_023779625.1 hypothetical protein -
M5D98_RS12470 (M5D98_12470) 2583979..2584278 - 300 WP_023779626.1 HigA family addiction module antitoxin Antitoxin
M5D98_RS12475 (M5D98_12475) 2584293..2584574 - 282 WP_224687692.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5D98_RS12480 (M5D98_12480) 2584692..2586218 - 1527 WP_224687691.1 ABC-F family ATP-binding cassette domain-containing protein -
M5D98_RS12485 (M5D98_12485) 2586594..2587499 - 906 WP_224687690.1 DMT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-79)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10508.86 Da        Isoelectric Point: 10.2058

>T245038 WP_224687692.1 NZ_CP097252:c2584574-2584293 [Mesorhizobium opportunistum]
MIRSFKDKTSEAVSNGKSPKGFPSDLVRSAQRKLFMIDNATELSDLKTPPGNRLESLKGNRAGQHSIRINDQFRICFRWV
NGQAEGVEITDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11173.99 Da        Isoelectric Point: 6.4700

>AT245038 WP_023779626.1 NZ_CP097252:c2584278-2583979 [Mesorhizobium opportunistum]
MLNINPPIHPGEILREEYLVPLGLKPYTLAKKLHVPRTRIERLAGETTPVTPDTALRLAKFFGTTPQFWMNMQASYDLAV
EGEAKKADLETIERLETVA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References