Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2866321..2867096 Replicon chromosome
Accession NZ_CP097248
Organism Klebsiella pneumoniae strain NTU107224

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A332L402
Locus tag M5D84_RS13945 Protein ID WP_021314147.1
Coordinates 2866611..2867096 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag M5D84_RS13940 Protein ID WP_004150912.1
Coordinates 2866321..2866614 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5D84_RS13920 (2861529) 2861529..2862131 - 603 WP_002916735.1 short chain dehydrogenase -
M5D84_RS13925 (2862229) 2862229..2863140 + 912 WP_004188550.1 LysR family transcriptional regulator -
M5D84_RS13930 (2863141) 2863141..2864289 - 1149 WP_032417597.1 PLP-dependent aspartate aminotransferase family protein -
M5D84_RS13935 (2864300) 2864300..2865676 - 1377 WP_073553579.1 cystathionine beta-synthase -
M5D84_RS13940 (2866321) 2866321..2866614 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
M5D84_RS13945 (2866611) 2866611..2867096 + 486 WP_021314147.1 GNAT family N-acetyltransferase Toxin
M5D84_RS13950 (2867800) 2867800..2868393 + 594 WP_004188553.1 hypothetical protein -
M5D84_RS13955 (2868490) 2868490..2868706 + 217 Protein_2712 transposase -
M5D84_RS13965 (2869221) 2869221..2869934 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2868490..2868642 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17621.68 Da        Isoelectric Point: 8.5144

>T245027 WP_021314147.1 NZ_CP097248:2866611-2867096 [Klebsiella pneumoniae]
MILAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT245027 WP_004150912.1 NZ_CP097248:2866321-2866614 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A332L402

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References