Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1987733..1988330 Replicon chromosome
Accession NZ_CP097232
Organism Klebsiella pneumoniae strain 4

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag M4269_RS09745 Protein ID WP_004142563.1
Coordinates 1988013..1988330 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag M4269_RS09740 Protein ID WP_004142561.1
Coordinates 1987733..1988020 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4269_RS09710 (1983813) 1983813..1984061 + 249 WP_002893037.1 DUF1158 domain-containing protein -
M4269_RS09715 (1984079) 1984079..1984420 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
M4269_RS09720 (1984451) 1984451..1985566 - 1116 WP_020316605.1 MBL fold metallo-hydrolase -
M4269_RS09725 (1985746) 1985746..1986327 + 582 WP_043906838.1 TetR/AcrR family transcriptional regulator -
M4269_RS09730 (1986327) 1986327..1986695 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
M4269_RS09735 (1986815) 1986815..1987465 + 651 Protein_1918 oxygen-insensitive NAD(P)H nitroreductase -
M4269_RS09740 (1987733) 1987733..1988020 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
M4269_RS09745 (1988013) 1988013..1988330 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M4269_RS09750 (1988515) 1988515..1989558 - 1044 WP_004178895.1 DUF2157 domain-containing protein -
M4269_RS09755 (1990225) 1990225..1991091 - 867 WP_004178894.1 helix-turn-helix transcriptional regulator -
M4269_RS09760 (1991200) 1991200..1992627 + 1428 WP_043906839.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T244987 WP_004142563.1 NZ_CP097232:c1988330-1988013 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT244987 WP_004142561.1 NZ_CP097232:c1988020-1987733 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References