Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 389332..389929 Replicon chromosome
Accession NZ_CP097220
Organism Klebsiella pneumoniae strain 12

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag M4272_RS01880 Protein ID WP_004142563.1
Coordinates 389332..389649 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag M4272_RS01885 Protein ID WP_004142561.1
Coordinates 389642..389929 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4272_RS01865 (385035) 385035..386462 - 1428 WP_043906839.1 MFS transporter -
M4272_RS01870 (386571) 386571..387437 + 867 WP_004178894.1 helix-turn-helix transcriptional regulator -
M4272_RS01875 (388104) 388104..389147 + 1044 WP_004178895.1 DUF2157 domain-containing protein -
M4272_RS01880 (389332) 389332..389649 + 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M4272_RS01885 (389642) 389642..389929 + 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
M4272_RS01890 (390197) 390197..390847 - 651 Protein_367 oxygen-insensitive NAD(P)H nitroreductase -
M4272_RS01895 (390967) 390967..391335 - 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
M4272_RS01900 (391335) 391335..391916 - 582 WP_043906838.1 TetR/AcrR family transcriptional regulator -
M4272_RS01905 (392096) 392096..393211 + 1116 Protein_370 MBL fold metallo-hydrolase -
M4272_RS01910 (393242) 393242..393583 + 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
M4272_RS01915 (393601) 393601..393849 - 249 WP_002893037.1 DUF1158 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T244933 WP_004142563.1 NZ_CP097220:389332-389649 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT244933 WP_004142561.1 NZ_CP097220:389642-389929 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References