Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2473382..2474020 Replicon chromosome
Accession NZ_CP097213
Organism Escherichia coli strain BE311

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag M3O69_RS11945 Protein ID WP_001447010.1
Coordinates 2473844..2474020 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M3O69_RS11940 Protein ID WP_001270286.1
Coordinates 2473382..2473798 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3O69_RS11920 (2468534) 2468534..2469475 - 942 WP_001251304.1 ABC transporter permease -
M3O69_RS11925 (2469476) 2469476..2470489 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
M3O69_RS11930 (2470507) 2470507..2471652 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
M3O69_RS11935 (2471897) 2471897..2473303 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
M3O69_RS11940 (2473382) 2473382..2473798 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
M3O69_RS11945 (2473844) 2473844..2474020 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
M3O69_RS11950 (2474242) 2474242..2474472 + 231 WP_000494244.1 YncJ family protein -
M3O69_RS11955 (2474564) 2474564..2476525 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
M3O69_RS11960 (2476598) 2476598..2477134 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
M3O69_RS11965 (2477226) 2477226..2478401 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2478441..2479589 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T244918 WP_001447010.1 NZ_CP097213:c2474020-2473844 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT244918 WP_001270286.1 NZ_CP097213:c2473798-2473382 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References