Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1899787..1900289 Replicon chromosome
Accession NZ_CP097213
Organism Escherichia coli strain BE311

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7I6H4L3
Locus tag M3O69_RS09105 Protein ID WP_000767831.1
Coordinates 1900035..1900289 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag M3O69_RS09100 Protein ID WP_001259255.1
Coordinates 1899787..1900038 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3O69_RS09075 (1894964) 1894964..1896031 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
M3O69_RS09080 (1896031) 1896031..1897101 - 1071 WP_000108939.1 histidinol-phosphate transaminase -
M3O69_RS09085 (1897098) 1897098..1898402 - 1305 WP_001375298.1 histidinol dehydrogenase -
M3O69_RS09090 (1898408) 1898408..1899307 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
M3O69_RS09095 (1899453) 1899453..1899503 - 51 WP_001364200.1 his operon leader peptide -
M3O69_RS09100 (1899787) 1899787..1900038 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
M3O69_RS09105 (1900035) 1900035..1900289 + 255 WP_000767831.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
M3O69_RS09110 (1900372) 1900372..1901196 + 825 WP_000754737.1 SDR family oxidoreductase -
M3O69_RS09115 (1901242) 1901242..1902171 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
M3O69_RS09120 (1902386) 1902386..1902448 + 63 WP_010723108.1 membrane protein YoeI -
M3O69_RS09125 (1902438) 1902438..1903796 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
M3O69_RS09130 (1903975) 1903975..1905033 + 1059 WP_000492316.1 thiosulfate utilization transporter TsuA/YeeE -
M3O69_RS09135 (1905047) 1905047..1905274 + 228 WP_000985278.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10231.67 Da        Isoelectric Point: 8.8202

>T244911 WP_000767831.1 NZ_CP097213:1900035-1900289 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTYDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT244911 WP_001259255.1 NZ_CP097213:1899787-1900038 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7I6H4L3

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References