24491

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 3657393..3658711 Replicon chromosome
Accession NC_013654
Organism Escherichia coli SE15

Toxin (Protein)


Gene name HipT Uniprot ID F4T5A3
Locus tag ECSF_RS17945 Protein ID WP_001262467.1
Coordinates 3657393..3658400 (-) Length 336 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID F4T5A4
Locus tag ECSF_RS17950 Protein ID WP_001312177.1
Coordinates 3658400..3658711 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECSF_RS17910 3652603..3652794 + 192 WP_000988308.1 cellulose biosynthesis protein BcsF -
ECSF_RS17915 3652791..3654470 + 1680 WP_000191554.1 cellulose biosynthesis protein BcsG -
ECSF_RS25180 3654556..3654663 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
ECSF_RS26015 3655039..3655146 - 108 WP_000170748.1 type I toxin-antitoxin system toxin Ldr family protein -
- 3655203..3655260 + 58 NuclAT_26 - -
- 3655203..3655260 + 58 NuclAT_26 - -
- 3655203..3655260 + 58 NuclAT_26 - -
- 3655203..3655260 + 58 NuclAT_26 - -
ECSF_RS25195 3655522..3655629 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
- 3655678..3655743 + 66 NuclAT_27 - -
- 3655678..3655743 + 66 NuclAT_27 - -
- 3655678..3655743 + 66 NuclAT_27 - -
- 3655678..3655743 + 66 NuclAT_27 - -
ECSF_RS17940 3656105..3657376 + 1272 WP_001545666.1 amino acid permease -
ECSF_RS17945 3657393..3658400 - 1008 WP_001262467.1 HipA domain-containing protein Toxin
ECSF_RS17950 3658400..3658711 - 312 WP_001312177.1 HipA N-terminal domain-containing protein Antitoxin
ECSF_RS17955 3658696..3659019 - 324 WP_000563102.1 helix-turn-helix transcriptional regulator -
ECSF_RS17960 3659244..3660257 - 1014 WP_000103572.1 dipeptide ABC transporter ATP-binding subunit DppF -
ECSF_RS17965 3660254..3661237 - 984 WP_001196477.1 dipeptide ABC transporter ATP-binding protein -
ECSF_RS17970 3661248..3662150 - 903 WP_000084677.1 dipeptide ABC transporter permease DppC -
ECSF_RS17975 3662160..3663179 - 1020 WP_000938855.1 dipeptide ABC transporter permease DppB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 336 a.a.        Molecular weight: 38320.60 Da        Isoelectric Point: 5.5965

>T24491 WP_001262467.1 NC_013654:c3658400-3657393 [Escherichia coli SE15]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDNKGLPVHQEQLDGAMQIMD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFHSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL

Download         Length: 1008 bp

>T24491 NC_013654:c3658400-3657393 [Escherichia coli SE15]
ATGGCGAATTGTCGTATTCTGTTAACGCCGTTGAATGAACGTGACGAACAGCGCGGATATTCGACACAGGGGTTGAAGCG
ACTGAGCGGCACTGCAAAATTGACCCCCAGGCTGGGGTTTACGCGAACTCAGTTTGTGCAGGAACTTCCGCGTCAACAAA
AAGGGATGAGTATTTCCGGTTACCAGCCCAAATTGCAATTAGTGCTGGATGAAGGAGAGTTCCGCGTCGTAGATCATCAG
GGAAATTTTATCCTTAAGCCCTCTCCAGCCGACTTTCCCGGTTTGGCCGAAAATGAACACGCAACAATGACATTGATGTC
TCGTTTGGGATTTGACGTACCTGTGCATGGCCTGTTGAGTTTTGCACCACAATCAGAGGAAGAGCTTGAATACGCATTTG
TTATCCGGCGCTATGACCGGGATAACAAGGGGCTGCCAGTGCATCAGGAACAGCTTGATGGCGCGATGCAGATTATGGAT
AAATATGGCAAAACGGGGAATGATAACGAACAATATGTCAGCTATGAAACGCTGGCCCGATTTTTAGTTGCCCATGTTAA
CGACAACATCGCATTTAAAATCGATCTCTTTCGTCGCATTGTTTACGCCTGGTTGCTGGGTAATAACGACATGCATTTAC
GAAACTTTGGCTTAGTGTACTCCGATGGTTTGACGCCAGCGTTAGCGCCGGTGTATGACTTTGTTTCTGTCGCTCCCTAT
CCGGAATATTTTCACTCAAACTATCTGGCGCTGCCGTTATTGACGCGAGAAGAAGGCGGTCGGGAGCTGGCTCCTGGATT
TCACAGTGATTATGGCGAGTATATCGGGCAGGACTTTTTGCTGTTGGGTGAATCAATGGGGTTAGCGCCCAGATTGCTGG
AAAAACTCTTTCAGGATATACGTAAAGAAAATGCCATTGTTATGGAAACGTATGAGCAGTCCTTTATGACTCAGGATCAT
ATCCAGGCTGTGCTGCAATGCTATCGACATCGTCTGGGGCTGCTGTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11821.47 Da        Isoelectric Point: 6.0609

>AT24491 WP_001312177.1 NC_013654:c3658711-3658400 [Escherichia coli SE15]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAPDYHGPAISISLPVAQRQFPSEMLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE

Download         Length: 312 bp

>AT24491 NC_013654:c3658711-3658400 [Escherichia coli SE15]
ATGCATCGGCGAGTGAAAGTGTTGCTCTATGGTCAGGTAGTGGGTGAACTCTCTCAGAACGACAGTGGTTTTTTGTTCCA
GTATGCCCCGGATTACCACGGACCGGCAATCTCAATCAGCCTGCCCGTCGCACAGCGTCAGTTTCCCAGTGAGATGTTGC
ATCCTTATTTCGCCTCACTGGCGCCAGAAGGATGGCTGCGTCAACGCTACAGCCAGATACAGCATCGTGACGAAAACGAT
CTGCTGGGAATGCTTATTGATAACGGCAAGAATCTGCTGGGGGCCATCCAGATTTTACCTTGGGAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3K2ZTB5

Antitoxin

Source ID Structure
AlphaFold DB A0A3L3HKE2

References