Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2482777..2483415 Replicon chromosome
Accession NZ_CP097181
Organism Escherichia coli strain SH21PTE31

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag M4R35_RS12145 Protein ID WP_000813794.1
Coordinates 2483239..2483415 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M4R35_RS12140 Protein ID WP_001270286.1
Coordinates 2482777..2483193 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4R35_RS12120 (2477929) 2477929..2478870 - 942 WP_001251304.1 ABC transporter permease -
M4R35_RS12125 (2478871) 2478871..2479884 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
M4R35_RS12130 (2479902) 2479902..2481047 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
M4R35_RS12135 (2481292) 2481292..2482698 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
M4R35_RS12140 (2482777) 2482777..2483193 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
M4R35_RS12145 (2483239) 2483239..2483415 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
M4R35_RS12150 (2483637) 2483637..2483867 + 231 WP_000494244.1 YncJ family protein -
M4R35_RS12155 (2483959) 2483959..2485920 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
M4R35_RS12160 (2485993) 2485993..2486529 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
M4R35_RS12165 (2486621) 2486621..2487796 + 1176 WP_064670497.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2487836..2488984 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T244873 WP_000813794.1 NZ_CP097181:c2483415-2483239 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT244873 WP_001270286.1 NZ_CP097181:c2483193-2482777 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References