Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2505077..2505639 Replicon chromosome
Accession NZ_CP097170
Organism Escherichia coli strain AR13438

Toxin (Protein)


Gene name higB Uniprot ID L4J948
Locus tag M3M51_RS11895 Protein ID WP_000605676.1
Coordinates 2505361..2505639 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag M3M51_RS11890 Protein ID WP_000781370.1
Coordinates 2505077..2505361 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3M51_RS11875 (2500436) 2500436..2503483 + 3048 WP_012311994.1 formate dehydrogenase-N subunit alpha -
M3M51_RS11880 (2503496) 2503496..2504380 + 885 WP_001240582.1 formate dehydrogenase N subunit beta -
M3M51_RS11885 (2504373) 2504373..2505026 + 654 WP_000045650.1 formate dehydrogenase-N subunit gamma -
M3M51_RS11890 (2505077) 2505077..2505361 - 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
M3M51_RS11895 (2505361) 2505361..2505639 - 279 WP_000605676.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M3M51_RS11900 (2505825) 2505825..2506835 - 1011 WP_000642407.1 alcohol dehydrogenase AdhP -
M3M51_RS11905 (2506969) 2506969..2508666 - 1698 WP_000433464.1 malate dehydrogenase -
M3M51_RS11910 (2508823) 2508823..2508960 - 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
M3M51_RS11915 (2509062) 2509062..2509277 - 216 WP_000495766.1 biofilm-dependent modulation protein -
M3M51_RS11920 (2509622) 2509622..2510053 + 432 WP_000152305.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10521.10 Da        Isoelectric Point: 7.3562

>T244839 WP_000605676.1 NZ_CP097170:c2505639-2505361 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT244839 WP_000781370.1 NZ_CP097170:c2505361-2505077 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G6T1

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References