Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 690290..691089 Replicon chromosome
Accession NZ_CP097170
Organism Escherichia coli strain AR13438

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag M3M51_RS03320 Protein ID WP_000347273.1
Coordinates 690290..690754 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID D6JF08
Locus tag M3M51_RS03325 Protein ID WP_001308975.1
Coordinates 690754..691089 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3M51_RS03290 (685291) 685291..685725 - 435 WP_000948834.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
M3M51_RS03295 (685743) 685743..686621 - 879 WP_001298314.1 PTS N-acetylgalactosamine transporter subunit IID -
M3M51_RS03300 (686611) 686611..687390 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
M3M51_RS03305 (687401) 687401..687874 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
M3M51_RS03310 (687897) 687897..689177 - 1281 WP_000681961.1 tagatose-bisphosphate aldolase subunit KbaZ -
M3M51_RS03315 (689426) 689426..690235 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
M3M51_RS03320 (690290) 690290..690754 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
M3M51_RS03325 (690754) 690754..691089 - 336 WP_001308975.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
M3M51_RS03330 (691238) 691238..692809 - 1572 WP_001273756.1 galactarate dehydratase -
M3M51_RS03335 (693184) 693184..694518 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
M3M51_RS03340 (694534) 694534..695304 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T244832 WP_000347273.1 NZ_CP097170:c690754-690290 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12343.97 Da        Isoelectric Point: 4.8616

>AT244832 WP_001308975.1 NZ_CP097170:c691089-690754 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB D6JF08

References