Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2379088..2379692 Replicon chromosome
Accession NZ_CP097108
Organism Pseudomonas bijieensis strain SP1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag M3M50_RS10425 Protein ID WP_116831887.1
Coordinates 2379378..2379692 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A6N1CCA5
Locus tag M3M50_RS10420 Protein ID WP_058545613.1
Coordinates 2379088..2379375 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3M50_RS10395 (M3M50_10395) 2375145..2376194 + 1050 WP_249016166.1 NAD(P)-dependent alcohol dehydrogenase -
M3M50_RS10400 (M3M50_10400) 2376321..2377538 + 1218 WP_176688261.1 MFS transporter -
M3M50_RS10405 (M3M50_10405) 2377550..2377957 - 408 WP_163854612.1 DoxX family protein -
M3M50_RS10410 (M3M50_10410) 2378015..2378443 + 429 WP_233459536.1 helix-turn-helix domain-containing protein -
M3M50_RS10415 (M3M50_10415) 2378459..2378944 - 486 WP_176688260.1 hypothetical protein -
M3M50_RS10420 (M3M50_10420) 2379088..2379375 - 288 WP_058545613.1 helix-turn-helix domain-containing protein Antitoxin
M3M50_RS10425 (M3M50_10425) 2379378..2379692 - 315 WP_116831887.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M3M50_RS10430 (M3M50_10430) 2379823..2380254 + 432 WP_116831888.1 arsenic resistance N-acetyltransferase ArsN2 -
M3M50_RS10435 (M3M50_10435) 2380251..2381609 - 1359 WP_109751620.1 chromate efflux transporter -
M3M50_RS10440 (M3M50_10440) 2381788..2382447 + 660 WP_116831889.1 ribonuclease T2 -
M3M50_RS10445 (M3M50_10445) 2382659..2384230 + 1572 WP_212802157.1 GGDEF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(42-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-86)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11934.03 Da        Isoelectric Point: 10.1359

>T244797 WP_116831887.1 NZ_CP097108:c2379692-2379378 [Pseudomonas bijieensis]
MIFIETPIFTRRVKELMDDDDFAVLQKILVCNPSAGDVMEATGGIRKIRIAAKGHGKRGGARVIYYHFVHASRIALLMIY
PKNEQQDLTVDQRKALKLIVEHWR

Download         Length: 315 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10741.40 Da        Isoelectric Point: 8.7885

>AT244797 WP_058545613.1 NZ_CP097108:c2379375-2379088 [Pseudomonas bijieensis]
MSKFFDELMESVQQMDEIVRGERQPSREFIVDALQVKEIRKATGLTQAKFAALIDVQLGTLRNWEQGRREPTGPAKALLR
AIHNDPKHVISALAV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6N1CCA5

References