Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1272695..1273200 Replicon chromosome
Accession NZ_CP097107
Organism Citrobacter freundii strain GMU8049

Toxin (Protein)


Gene name yoeB Uniprot ID A0A5H6P158
Locus tag M3L74_RS06580 Protein ID WP_023218457.1
Coordinates 1272695..1272955 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5H6P2W8
Locus tag M3L74_RS06585 Protein ID WP_052932205.1
Coordinates 1272955..1273200 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3L74_RS06560 (1268237) 1268237..1268830 - 594 WP_003845054.1 Slp family lipoprotein -
M3L74_RS06565 (1268954) 1268954..1269208 - 255 WP_003845055.1 DUF1471 domain-containing protein -
M3L74_RS06570 (1269728) 1269728..1271626 + 1899 WP_088903227.1 methyl-accepting chemotaxis protein -
M3L74_RS06575 (1271801) 1271801..1272430 + 630 WP_003028217.1 DNA-binding protein -
M3L74_RS06580 (1272695) 1272695..1272955 - 261 WP_023218457.1 Txe/YoeB family addiction module toxin Toxin
M3L74_RS06585 (1272955) 1272955..1273200 - 246 WP_052932205.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
M3L74_RS06590 (1273683) 1273683..1273945 + 263 Protein_1219 ogr/Delta-like zinc finger family protein -
M3L74_RS06595 (1274138) 1274138..1274443 - 306 WP_087878867.1 hypothetical protein -
M3L74_RS06600 (1274966) 1274966..1276612 + 1647 WP_232481245.1 phage tailspike protein -
M3L74_RS06605 (1276710) 1276710..1277912 + 1203 WP_160179992.1 acyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - acrB 1251493..1278943 27450


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10202.88 Da        Isoelectric Point: 10.2570

>T244786 WP_023218457.1 NZ_CP097107:c1272955-1272695 [Citrobacter freundii]
MKVRISPQAKSDLQYWAETDPKTHNKVMELIKSAKESPFKGIGKPEALKHRKPLWSRRITKEHRLVYYVEQGDLYIVACR
YHYTTI

Download         Length: 261 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9036.05 Da        Isoelectric Point: 4.4180

>AT244786 WP_052932205.1 NZ_CP097107:c1273200-1272955 [Citrobacter freundii]
MQHVNYTDARQHLADLMQQANDDRAPILVTRKGAKSVVMIDAEEFASIQETLHLFSNPANAAHIEASLASLERGDYEELD
I

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H6P158

Antitoxin

Source ID Structure
AlphaFold DB A0A5H6P2W8

References