Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1244638..1245224 Replicon chromosome
Accession NZ_CP097103
Organism Pseudomonas sp. NY11382

Toxin (Protein)


Gene name graT Uniprot ID A0A6I2K6L8
Locus tag M2J80_RS05665 Protein ID WP_029885077.1
Coordinates 1244946..1245224 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag M2J80_RS05660 Protein ID WP_029885078.1
Coordinates 1244638..1244937 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2J80_RS05635 (M2J80_05620) 1240524..1241333 + 810 WP_161891667.1 tRNA cyclic N6-threonylcarbamoyladenosine(37) synthase TcdA -
M2J80_RS05640 (M2J80_05625) 1241405..1241815 - 411 WP_161891668.1 SufE family protein -
M2J80_RS05645 (M2J80_05630) 1241812..1243017 - 1206 WP_161891669.1 cysteine desulfurase -
M2J80_RS05650 (M2J80_05635) 1243099..1244133 - 1035 WP_009686960.1 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase -
M2J80_RS05655 (M2J80_05640) 1244165..1244512 - 348 WP_054881204.1 ArsC family reductase -
M2J80_RS05660 (M2J80_05645) 1244638..1244937 - 300 WP_029885078.1 type II toxin-antitoxin system antitoxin GraA Antitoxin
M2J80_RS05665 (M2J80_05650) 1244946..1245224 - 279 WP_029885077.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2J80_RS05670 (M2J80_05655) 1245473..1247119 + 1647 WP_054890073.1 Na+/H+ antiporter -
M2J80_RS05675 (M2J80_05660) 1248158..1249354 - 1197 WP_110678255.1 succinyldiaminopimelate transaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10420.72 Da        Isoelectric Point: 7.1344

>T244779 WP_029885077.1 NZ_CP097103:c1245224-1244946 [Pseudomonas sp. NY11382]
MIQSFSCADTEALFVTGKTRRWSDIKSVAERKLAMLDAATELRDLRSPPGNRLEALSGNRAGQHSIRVNDQWRLCFTWTD
NGPANVEIIDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10903.58 Da        Isoelectric Point: 6.4603

>AT244779 WP_029885078.1 NZ_CP097103:c1244937-1244638 [Pseudomonas sp. NY11382]
MLKNGMRPIHPGEVLREDFQKEMGFSAAALARALGVATPTVNNILRERGGVSADMALRLSICLDTTPEFWLNLQTAFDLR
TAEQRHGEEIIGAVQRLVA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I2K6L8

Antitoxin

Source ID Structure

References