Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2642854..2643190 Replicon chromosome
Accession NZ_CP097069
Organism Enterococcus faecalis strain AT40a

Toxin (Protein)


Gene name txpA Uniprot ID A0A1J6YG70
Locus tag M2912_RS12715 Protein ID WP_002396786.1
Coordinates 2642854..2642997 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2643141..2643190 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2912_RS12695 2638132..2638347 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
M2912_RS12700 2638486..2639478 + 993 WP_002394775.1 biotin--[acetyl-CoA-carboxylase] ligase -
M2912_RS12705 2639645..2640283 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
M2912_RS12710 2640968..2642584 + 1617 WP_010710855.1 phosphatase PAP2/LCP family protein -
M2912_RS12715 2642854..2642997 + 144 WP_002396786.1 putative holin-like toxin Toxin
- 2643141..2643190 + 50 - - Antitoxin
M2912_RS12720 2643192..2647883 - 4692 WP_010710853.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5203.19 Da        Isoelectric Point: 8.6626

>T244707 WP_002396786.1 NZ_CP097069:2642854-2642997 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 50 bp

>AT244707 NZ_CP097069:2643141-2643190 [Enterococcus faecalis]
AATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J6YG70

Antitoxin

Download structure file

References