Detailed information of TA system TA244699

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2499850..2500111
• Replicon: chromosome
• Accession: NZ_CP097069
• Organism: Enterococcus faecalis strain AT40a

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: M2912_RS12065
• Protein ID: WP_224561205.1
• Coordinates: 2500010..2500111 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2499850..2500061 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M2912_RS12040	2495534..2496487	-	954	WP_002359060.1	siderophore ABC transporter substrate-binding protein	-
M2912_RS12045	2496526..2497281	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
M2912_RS12050	2497278..2498243	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
M2912_RS12055	2498240..2499187	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
M2912_RS12060	2499372..2499824	+	453	WP_002378807.1	YueI family protein	-
-	2499850..2500061	+	212	-	-	Antitoxin
M2912_RS12065	2500010..2500111	-	102	WP_224561205.1	putative holin-like toxin	Toxin
M2912_RS12070	2500302..2502572	-	2271	WP_078122760.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
M2912_RS12075	2502743..2503249	+	507	WP_002378810.1	cysteine hydrolase family protein	-
M2912_RS12080	2503439..2504335	+	897	WP_002365354.1	YitT family protein	-
M2912_RS12085	2504386..2504784	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3629.37 Da
• Isoelectric Point: 4.5869

>T244699 WP_224561205.1 NZ_CP097069:c2500111-2500010 [Enterococcus faecalis]
MSIEATLELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 212 bp

>AT244699 NZ_CP097069:2499850-2500061 [Enterococcus faecalis]
TTCCATTTATAATAGAATTATGCTATTATGAAAATGAAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAAC
ACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGG
TTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin