Detailed information of TA system TA244691

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2662584..2662920
• Replicon: chromosome
• Accession: NZ_CP097066
• Organism: Enterococcus faecalis strain AT49a

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: M2922_RS12660
• Protein ID: WP_016619108.1
• Coordinates: 2662584..2662727 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2662871..2662920 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M2922_RS12640 (2657776)	2657776..2658768	+	993	WP_002378862.1	biotin--[acetyl-CoA-carboxylase] ligase	-
M2922_RS12645 (2658935)	2658935..2659573	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
M2922_RS12650 (2660259)	2660259..2661875	+	1617	WP_174114069.1	phosphatase PAP2/LCP family protein	-
M2922_RS12655 (2662204)	2662204..2662353	+	150	WP_002411240.1	type I toxin-antitoxin system toxin PepG1	-
- (2662327)	2662327..2662473	-	147	NuclAT_12	-	-
- (2662286)	2662286..2662487	-	202	NuclAT_8	-	-
M2922_RS12660 (2662584)	2662584..2662727	+	144	WP_016619108.1	putative holin-like toxin	Toxin
- (2662871)	2662871..2662920	+	50	NuclAT_16	-	Antitoxin
- (2662659)	2662659..2662921	-	263	NuclAT_11	-	-
M2922_RS12665 (2662922)	2662922..2667613	-	4692	WP_174114070.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5191.13 Da
• Isoelectric Point: 8.6626

>T244691 WP_016619108.1 NZ_CP097066:2662584-2662727 [Enterococcus faecalis]
MNVSTKTYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 50 bp

>AT244691 NZ_CP097066:2662871-2662920 [Enterococcus faecalis]
AATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATT

Structures

Antitoxin