Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2570990..2571432 Replicon chromosome
Accession NZ_CP097066
Organism Enterococcus faecalis strain AT49a

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag M2922_RS12225 Protein ID WP_002392696.1
Coordinates 2570990..2571133 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2571234..2571432 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2922_RS12210 (2566239) 2566239..2566952 - 714 WP_002354877.1 trehalose operon repressor -
M2922_RS12215 (2567213) 2567213..2569957 + 2745 WP_174113967.1 glycoside hydrolase family 65 protein -
M2922_RS12220 (2569972) 2569972..2570622 + 651 WP_002354875.1 beta-phosphoglucomutase -
- (2570691) 2570691..2570824 + 134 NuclAT_15 - -
- (2570871) 2570871..2571016 + 146 NuclAT_13 - -
- (2570871) 2570871..2571057 + 187 NuclAT_10 - -
M2922_RS12225 (2570990) 2570990..2571133 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 Toxin
- (2571246) 2571246..2571391 + 146 NuclAT_14 - -
- (2571234) 2571234..2571432 + 199 NuclAT_9 - Antitoxin
M2922_RS12230 (2571365) 2571365..2571508 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 -
M2922_RS13485 (2571916) 2571916..2572041 - 126 WP_002383214.1 hypothetical protein -
M2922_RS12235 (2572246) 2572246..2572452 + 207 WP_258075960.1 CPBP family intramembrane metalloprotease -
M2922_RS12240 (2572505) 2572505..2573476 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
M2922_RS12245 (2573651) 2573651..2574088 - 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
M2922_RS12250 (2574221) 2574221..2574775 - 555 WP_002354869.1 Maf family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T244678 WP_002392696.1 NZ_CP097066:c2571133-2570990 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 199 bp

>AT244678 NZ_CP097066:2571234-2571432 [Enterococcus faecalis]
TTTTTAGGGAAATGTGCTATAATGAAAATGAAAAGAGAGATATGCTTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGA
CGGTGACCGATTATATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAATT
TCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References