244675

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2496402..2496628 Replicon chromosome
Accession NZ_CP097066
Organism Enterococcus faecalis strain AT49a

Toxin (Protein)


Gene name txpA Uniprot ID -
Locus tag M2922_RS11880 Protein ID WP_224561205.1
Coordinates 2496527..2496628 (-) Length 34 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2496402..2496582 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2922_RS11850 (2491620) 2491620..2492573 - 954 WP_174114190.1 siderophore ABC transporter substrate-binding protein -
M2922_RS11855 (2492612) 2492612..2493367 - 756 WP_002354962.1 ATP-binding cassette domain-containing protein -
M2922_RS11860 (2493364) 2493364..2494329 - 966 WP_002354961.1 iron chelate uptake ABC transporter family permease subunit -
M2922_RS11865 (2494326) 2494326..2495273 - 948 WP_002354960.1 iron chelate uptake ABC transporter family permease subunit -
M2922_RS11870 (2495458) 2495458..2495910 + 453 WP_002354958.1 YueI family protein -
- (2495936) 2495936..2496143 + 208 NuclAT_4 - -
- (2495973) 2495973..2496147 + 175 NuclAT_7 - -
M2922_RS11875 (2496092) 2496092..2496193 - 102 WP_021164441.1 putative holin-like toxin -
- (2496368) 2496368..2496578 + 211 NuclAT_5 - -
- (2496402) 2496402..2496582 + 181 NuclAT_6 - Antitoxin
M2922_RS11880 (2496527) 2496527..2496628 - 102 WP_224561205.1 putative holin-like toxin Toxin
M2922_RS11885 (2496818) 2496818..2499088 - 2271 WP_002368430.1 bifunctional glutamate--cysteine ligase/glutathione synthetase -
M2922_RS11890 (2499259) 2499259..2499765 + 507 WP_174114188.1 cysteine hydrolase family protein -
M2922_RS11895 (2499955) 2499955..2500851 + 897 WP_002368434.1 YitT family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-33)


Sequences


Toxin        


Download         Length: 34 a.a.        Molecular weight: 3629.37 Da        Isoelectric Point: 4.5869

>T244675 WP_224561205.1 NZ_CP097066:c2496628-2496527 [Enterococcus faecalis]
MSIEATLELMISFAAFVALLIFGILEATKNDKK

Download         Length: 102 bp


Antitoxin


Download         Length: 181 bp

>AT244675 NZ_CP097066:2496402-2496582 [Enterococcus faecalis]
TGAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAG
TTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATAC
CGAAAATCAGTAGTGCAACAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References