Detailed information of TA system TA244668

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2495936..2496193
• Replicon: chromosome
• Accession: NZ_CP097066
• Organism: Enterococcus faecalis strain AT49a

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: M2922_RS11875
• Protein ID: WP_021164441.1
• Coordinates: 2496092..2496193 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2495936..2496143 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M2922_RS11850 (2491620)	2491620..2492573	-	954	WP_174114190.1	siderophore ABC transporter substrate-binding protein	-
M2922_RS11855 (2492612)	2492612..2493367	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
M2922_RS11860 (2493364)	2493364..2494329	-	966	WP_002354961.1	iron chelate uptake ABC transporter family permease subunit	-
M2922_RS11865 (2494326)	2494326..2495273	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
M2922_RS11870 (2495458)	2495458..2495910	+	453	WP_002354958.1	YueI family protein	-
- (2495936)	2495936..2496143	+	208	NuclAT_4	-	Antitoxin
- (2495973)	2495973..2496147	+	175	NuclAT_7	-	-
M2922_RS11875 (2496092)	2496092..2496193	-	102	WP_021164441.1	putative holin-like toxin	Toxin
- (2496368)	2496368..2496578	+	211	NuclAT_5	-	-
- (2496402)	2496402..2496582	+	181	NuclAT_6	-	-
M2922_RS11880 (2496527)	2496527..2496628	-	102	WP_224561205.1	putative holin-like toxin	-
M2922_RS11885 (2496818)	2496818..2499088	-	2271	WP_002368430.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
M2922_RS11890 (2499259)	2499259..2499765	+	507	WP_174114188.1	cysteine hydrolase family protein	-
M2922_RS11895 (2499955)	2499955..2500851	+	897	WP_002368434.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3598.36 Da
• Isoelectric Point: 6.0656

>T244668 WP_021164441.1 NZ_CP097066:c2496193-2496092 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNNKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 208 bp

>AT244668 NZ_CP097066:2495936-2496143 [Enterococcus faecalis]
TTCCATTTATAATAGAATTATGCTATTATAAAGATGAAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAAC
ACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTAT
TTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin