Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2748635..2749076 Replicon chromosome
Accession NZ_CP097059
Organism Enterococcus faecalis strain AT04

Toxin (Protein)


Gene name txpA Uniprot ID A0A1J6YG70
Locus tag M2902_RS13205 Protein ID WP_002396786.1
Coordinates 2748933..2749076 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2748635..2748836 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2902_RS13180 2744210..2745505 - 1296 WP_002396787.1 ATP-binding protein -
M2902_RS13185 2745967..2747583 + 1617 WP_002358967.1 phosphatase PAP2/LCP family protein -
M2902_RS13190 2747938..2748060 + 123 WP_002404776.1 putative holin-like toxin -
M2902_RS13195 2748246..2748443 + 198 WP_002358966.1 type I toxin-antitoxin system toxin PepG1 -
M2902_RS13200 2748562..2748702 + 141 WP_077143780.1 putative holin-like toxin -
- 2748635..2748836 - 202 - - Antitoxin
M2902_RS13205 2748933..2749076 + 144 WP_002396786.1 putative holin-like toxin Toxin
M2902_RS13210 2749271..2753962 - 4692 WP_085366674.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5203.19 Da        Isoelectric Point: 8.6626

>T244656 WP_002396786.1 NZ_CP097059:2748933-2749076 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 202 bp

>AT244656 NZ_CP097059:c2748836-2748635 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTGTAATAGCAATGAAAAGAGAGATATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGCGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J6YG70

Antitoxin

Download structure file

References