Detailed information of TA system TA024465

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 7744507..7745219
• Replicon: chromosome
• Accession: NC_013595
• Organism: Streptosporangium roseum DSM 43021

Toxin (Protein)

• Gene name: HigB2
• Uniprot ID: D2B8W1
• Locus tag: SROS_RS33850
• Protein ID: WP_012893447.1
• Coordinates: 7744507..7744893 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: SROS_RS33855
• Protein ID: WP_012893448.1
• Coordinates: 7744890..7745219 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SROS_RS46395	7740925..7741638	-	714	WP_012893444.1	hypothetical protein	-
SROS_RS33840	7742240..7742578	-	339	WP_012893445.1	helix-turn-helix transcriptional regulator	-
SROS_RS48085	7742575..7742967	-	393	WP_081453283.1	type II toxin-antitoxin system RelE/ParE family toxin	-
SROS_RS33845	7743420..7744034	+	615	WP_012893446.1	hypothetical protein	-
SROS_RS33850	7744507..7744893	+	387	WP_012893447.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SROS_RS33855	7744890..7745219	+	330	WP_012893448.1	helix-turn-helix transcriptional regulator	Antitoxin
SROS_RS33860	7745509..7746120	-	612	WP_012893449.1	hypothetical protein	-
SROS_RS33865	7746512..7746928	+	417	WP_148269287.1	lamin tail domain-containing protein	-
SROS_RS50165	7746992..7747228	+	237	WP_169369435.1	DUF4265 domain-containing protein	-
SROS_RS50170	7747350..7747799	+	450	WP_148269289.1	hypothetical protein	-
SROS_RS33870	7748059..7748766	+	708	WP_012893454.1	hypothetical protein	-
SROS_RS33875	7748793..7749398	-	606	WP_012893455.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	7728778..7762974	34196

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (22-111)

Antitoxin

• Cro/C1-type helix-turn-helix domain (43-96)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14697.68 Da
• Isoelectric Point: 4.5705

>T24465 WP_012893447.1 NC_013595:7744507-7744893 [Streptosporangium roseum DSM 43021]
MAWEIVLLEPVESWFLKLCESDPDSATLIERAIDRLAEAGPALGRPLVDTLEDDDLNNLKELRPGSRGRSEIRIVFIFDP
DREAIFLVAGDKAGKWSRWYDEAIPLAKSRYAEYCTEKKAEKTKEDRR

Nucleotide

• Length: 387 bp

>T24465 NC_013595:7744507-7744893 [Streptosporangium roseum DSM 43021]
ATGGCGTGGGAGATCGTTCTACTGGAGCCCGTAGAATCCTGGTTCCTCAAACTCTGCGAAAGCGATCCTGACTCCGCAAC
CCTCATCGAGAGGGCTATCGATCGACTCGCCGAGGCCGGTCCTGCCCTCGGCCGTCCCTTGGTGGACACGCTGGAGGATG
ATGACCTGAACAACCTGAAGGAACTCCGTCCAGGCTCCCGGGGGCGATCAGAGATTAGAATCGTCTTCATCTTCGATCCC
GACAGAGAAGCGATCTTCCTCGTGGCCGGGGACAAGGCAGGCAAGTGGTCGCGCTGGTATGACGAGGCGATCCCGCTGGC
CAAGTCCCGCTACGCGGAGTACTGCACGGAGAAGAAGGCCGAGAAGACCAAGGAGGACAGGCGATGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11667.16 Da
• Isoelectric Point: 6.3294

>AT24465 WP_012893448.1 NC_013595:7744890-7745219 [Streptosporangium roseum DSM 43021]
MSPARRWQEVKAEAHRLHPELAAPERQAAAEAELDAYVAGYHLKELRKSLGKTQADVAAALGISQSRVSQIENGDLDAME
LETLRAYAAALGGHVDVTISVGPHSVKVA

Nucleotide

• Length: 330 bp

>AT24465 NC_013595:7744890-7745219 [Streptosporangium roseum DSM 43021]
ATGAGTCCTGCGCGCCGCTGGCAGGAGGTCAAGGCCGAGGCCCACCGGCTCCATCCCGAGCTGGCCGCCCCGGAGCGACA
GGCCGCCGCCGAAGCCGAGCTGGATGCCTATGTGGCCGGCTACCACTTGAAGGAACTGCGCAAGTCTCTCGGCAAAACCC
AGGCCGACGTCGCCGCCGCGCTCGGCATCTCCCAGTCTCGGGTCTCCCAGATCGAGAACGGTGATCTCGACGCCATGGAG
CTGGAGACTCTCCGCGCTTATGCAGCCGCATTGGGTGGACACGTCGACGTCACGATCAGCGTCGGCCCGCACTCCGTCAA
GGTCGCCTGA

Structures

Toxin

• AlphaFold DB: D2B8W1