Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 7335889..7336559 Replicon chromosome
Accession NC_013595
Organism Streptosporangium roseum DSM 43021

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag SROS_RS32195 Protein ID WP_043657256.1
Coordinates 7335889..7336254 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag SROS_RS32200 Protein ID WP_012893107.1
Coordinates 7336251..7336559 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SROS_RS32175 7331351..7331632 + 282 WP_012893102.1 metalloregulator ArsR/SmtB family transcription factor -
SROS_RS32180 7332001..7333437 + 1437 WP_012893103.1 cytochrome ubiquinol oxidase subunit I -
SROS_RS32185 7333448..7334389 + 942 WP_012893104.1 cytochrome d ubiquinol oxidase subunit II -
SROS_RS32190 7334489..7335733 + 1245 WP_012893105.1 MFS transporter -
SROS_RS32195 7335889..7336254 + 366 WP_043657256.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SROS_RS32200 7336251..7336559 + 309 WP_012893107.1 helix-turn-helix transcriptional regulator Antitoxin
SROS_RS32205 7336825..7339233 - 2409 WP_012893108.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
SROS_RS32210 7339443..7339922 - 480 WP_012893109.1 (2Fe-2S)-binding protein -
SROS_RS32215 7340015..7340884 - 870 WP_012893110.1 xanthine dehydrogenase family protein subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(9-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-85)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13602.49 Da        Isoelectric Point: 7.3221

>T24464 WP_043657256.1 NC_013595:7335889-7336254 [Streptosporangium roseum DSM 43021]
MTGEVREWLHAMRAGDRATSRLIGQAIQTLVEIGPDPGRPLVDRITGSAVRNMKELRPGSSGRSEIRILFAFDPRRSAVL
LVAGDKAGHWEAWYDKAIPLAEERFAEWVAWLEASPKEHDR

Download         Length: 366 bp

>T24464 NC_013595:7335889-7336254 [Streptosporangium roseum DSM 43021]
ATGACGGGAGAAGTACGAGAGTGGCTGCACGCGATGAGAGCAGGCGATCGAGCGACTTCCCGGTTGATCGGCCAGGCGAT
CCAGACCCTCGTGGAGATAGGCCCCGATCCGGGACGGCCGTTGGTCGACAGGATCACAGGCTCCGCCGTACGGAATATGA
AGGAGCTACGGCCGGGCTCTTCGGGGCGGAGCGAGATCAGGATCCTGTTCGCCTTCGATCCTCGACGCAGCGCCGTGCTG
CTGGTCGCCGGAGACAAAGCCGGCCACTGGGAAGCCTGGTACGACAAGGCGATACCGCTGGCGGAGGAGCGGTTCGCCGA
ATGGGTGGCGTGGCTGGAAGCATCACCGAAGGAGCATGATCGATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11421.94 Da        Isoelectric Point: 5.6559

>AT24464 WP_012893107.1 NC_013595:7336251-7336559 [Streptosporangium roseum DSM 43021]
MTTFHRWDDVRHEVFDEEDLAAIDRGAAETVAAVRLAAMRKQLGLRQVDVAERMHVRQERVSAIERGEPTSATLSTLIAY
VRALGGQLEVVATVDDTRYKIA

Download         Length: 309 bp

>AT24464 NC_013595:7336251-7336559 [Streptosporangium roseum DSM 43021]
ATGACCACATTCCACCGATGGGACGACGTCAGGCATGAGGTCTTCGACGAAGAGGATCTCGCCGCCATCGACCGGGGCGC
CGCCGAGACGGTCGCCGCTGTCAGGCTTGCCGCCATGCGCAAGCAGCTCGGCCTGCGCCAGGTGGATGTCGCCGAGCGCA
TGCACGTGCGACAGGAAAGGGTTTCCGCGATCGAACGGGGAGAGCCGACCTCGGCGACACTGAGCACGCTGATCGCCTAT
GTCCGAGCGCTCGGCGGGCAGCTCGAGGTCGTCGCCACCGTCGACGACACCCGCTACAAGATCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References