Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2644626..2644900 Replicon chromosome
Accession NZ_CP097056
Organism Enterococcus faecalis strain AT09

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag M2903_RS12745 Protein ID WP_002392696.1
Coordinates 2644757..2644900 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2644626..2644824 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2903_RS12725 (2639631) 2639631..2640344 - 714 WP_002354877.1 trehalose operon repressor -
M2903_RS12730 (2640605) 2640605..2643349 + 2745 WP_174113967.1 glycoside hydrolase family 65 protein -
M2903_RS12735 (2643364) 2643364..2644014 + 651 WP_002354875.1 beta-phosphoglucomutase -
- (2644083) 2644083..2644216 + 134 NuclAT_15 - -
- (2644263) 2644263..2644408 + 146 NuclAT_13 - -
- (2644263) 2644263..2644449 + 187 NuclAT_10 - -
M2903_RS12740 (2644382) 2644382..2644525 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 -
- (2644638) 2644638..2644783 + 146 NuclAT_14 - -
- (2644626) 2644626..2644824 + 199 NuclAT_9 - Antitoxin
M2903_RS12745 (2644757) 2644757..2644900 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 Toxin
M2903_RS14420 (2645308) 2645308..2645433 - 126 WP_002383214.1 hypothetical protein -
M2903_RS12750 (2645638) 2645638..2645844 + 207 WP_258075960.1 CPBP family intramembrane metalloprotease -
M2903_RS12755 (2645897) 2645897..2646868 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
M2903_RS12760 (2647043) 2647043..2647480 - 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
M2903_RS12765 (2647613) 2647613..2648167 - 555 WP_002354869.1 Maf family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T244619 WP_002392696.1 NZ_CP097056:c2644900-2644757 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 199 bp

>AT244619 NZ_CP097056:2644626-2644824 [Enterococcus faecalis]
TTTTTAGGGAAATGTGCTATAATGAAAATGAAAAGAGAGATATGCTTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGA
CGGTGACCGATTATATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAATT
TCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References