Detailed information of TA system TA244610

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2569484..2569970
• Replicon: chromosome
• Accession: NZ_CP097056
• Organism: Enterococcus faecalis strain AT09

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: M2903_RS12390
• Protein ID: WP_021164441.1
• Coordinates: 2569484..2569585 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2569760..2569970 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M2903_RS12365 (2565012)	2565012..2565965	-	954	WP_174114190.1	siderophore ABC transporter substrate-binding protein	-
M2903_RS12370 (2566004)	2566004..2566759	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
M2903_RS12375 (2566756)	2566756..2567721	-	966	WP_002354961.1	iron chelate uptake ABC transporter family permease subunit	-
M2903_RS12380 (2567718)	2567718..2568665	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
M2903_RS12385 (2568850)	2568850..2569302	+	453	WP_002354958.1	YueI family protein	-
- (2569328)	2569328..2569535	+	208	NuclAT_4	-	-
- (2569365)	2569365..2569539	+	175	NuclAT_7	-	-
M2903_RS12390 (2569484)	2569484..2569585	-	102	WP_021164441.1	putative holin-like toxin	Toxin
- (2569760)	2569760..2569970	+	211	NuclAT_5	-	Antitoxin
- (2569794)	2569794..2569974	+	181	NuclAT_6	-	-
M2903_RS12395 (2569919)	2569919..2570020	-	102	WP_224561205.1	putative holin-like toxin	-
M2903_RS12400 (2570210)	2570210..2572480	-	2271	WP_002368430.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
M2903_RS12405 (2572651)	2572651..2573157	+	507	WP_174114188.1	cysteine hydrolase family protein	-
M2903_RS12410 (2573347)	2573347..2574243	+	897	WP_002368434.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3598.36 Da
• Isoelectric Point: 6.0656

>T244610 WP_021164441.1 NZ_CP097056:c2569585-2569484 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNNKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 211 bp

>AT244610 NZ_CP097056:2569760-2569970 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACA
CCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGT
TATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin