Detailed information of TA system TA244597

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2752520..2752857
• Replicon: chromosome
• Accession: NZ_CP097048
• Organism: Enterococcus faecalis strain AT22

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A1J6YG70
• Locus tag: M2906_RS13235
• Protein ID: WP_002396786.1
• Coordinates: 2752520..2752663 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2752595..2752857 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M2906_RS13215 (2747798)	2747798..2748013	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
M2906_RS13220 (2748152)	2748152..2749144	+	993	WP_002394775.1	biotin--[acetyl-CoA-carboxylase] ligase	-
M2906_RS13225 (2749311)	2749311..2749949	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
M2906_RS13230 (2750634)	2750634..2752250	+	1617	WP_010710855.1	phosphatase PAP2/LCP family protein	-
- (2752334)	2752334..2752409	-	76	NuclAT_7	-	-
- (2752307)	2752307..2752423	-	117	NuclAT_10	-	-
M2906_RS13235 (2752520)	2752520..2752663	+	144	WP_002396786.1	putative holin-like toxin	Toxin
- (2752807)	2752807..2752856	+	50	NuclAT_8	-	-
- (2752595)	2752595..2752857	-	263	NuclAT_5	-	Antitoxin
M2906_RS13240 (2752858)	2752858..2757549	-	4692	WP_010710853.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5203.19 Da
• Isoelectric Point: 8.6626

>T244597 WP_002396786.1 NZ_CP097048:2752520-2752663 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 263 bp

>AT244597 NZ_CP097048:c2752857-2752595 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTATA
ATAGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A1J6YG70

Antitoxin