Detailed information of TA system TA244592

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2666715..2666977
• Replicon: chromosome
• Accession: NZ_CP097048
• Organism: Enterococcus faecalis strain AT22

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: M2906_RS12845
• Protein ID: WP_002392696.1
• Coordinates: 2666834..2666977 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2666715..2666860 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M2906_RS12825 (2662080)	2662080..2662793	-	714	WP_002367455.1	trehalose operon repressor	-
M2906_RS12830 (2662855)	2662855..2663031	-	177	WP_002396826.1	hypothetical protein	-
M2906_RS12835 (2663055)	2663055..2665799	+	2745	WP_025191898.1	glycosyl hydrolase family 65 protein	-
M2906_RS12840 (2665814)	2665814..2666464	+	651	WP_002367457.1	beta-phosphoglucomutase	-
- (2666715)	2666715..2666860	+	146	NuclAT_6	-	Antitoxin
- (2666715)	2666715..2666901	+	187	NuclAT_9	-	-
M2906_RS12845 (2666834)	2666834..2666977	-	144	WP_002392696.1	type I toxin-antitoxin system toxin PepG1	Toxin
M2906_RS12850 (2667209)	2667209..2668180	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
M2906_RS12855 (2668355)	2668355..2668792	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
M2906_RS12860 (2668925)	2668925..2669479	-	555	WP_002354869.1	Maf family protein	-
M2906_RS12865 (2669504)	2669504..2671636	-	2133	WP_010710871.1	DNA mismatch repair endonuclease MutL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T244592 WP_002392696.1 NZ_CP097048:c2666977-2666834 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 146 bp

>AT244592 NZ_CP097048:2666715-2666860 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin