Detailed information of TA system TA244590

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2593781..2594005
• Replicon: chromosome
• Accession: NZ_CP097048
• Organism: Enterococcus faecalis strain AT22

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: M2906_RS12510
• Protein ID: WP_021164442.1
• Coordinates: 2593904..2594005 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2593781..2593967 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M2906_RS12485 (2589428)	2589428..2590381	-	954	WP_002408267.1	siderophore ABC transporter substrate-binding protein	-
M2906_RS12490 (2590420)	2590420..2591175	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
M2906_RS12495 (2591172)	2591172..2592137	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
M2906_RS12500 (2592134)	2592134..2593081	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
M2906_RS12505 (2593266)	2593266..2593718	+	453	WP_010710887.1	YueI family protein	-
- (2593744)	2593744..2593950	+	207	NuclAT_4	-	-
- (2593781)	2593781..2593967	+	187	NuclAT_3	-	Antitoxin
M2906_RS12510 (2593904)	2593904..2594005	-	102	WP_021164442.1	putative holin-like toxin	Toxin
M2906_RS12515 (2594196)	2594196..2596466	-	2271	WP_002368430.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
M2906_RS12520 (2596637)	2596637..2597143	+	507	WP_010710886.1	cysteine hydrolase family protein	-
M2906_RS12525 (2597333)	2597333..2598229	+	897	WP_002365354.1	YitT family protein	-
M2906_RS12530 (2598280)	2598280..2598678	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3625.38 Da
• Isoelectric Point: 4.5869

>T244590 WP_021164442.1 NZ_CP097048:c2594005-2593904 [Enterococcus faecalis]
MSIEATLELMISFATLVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 187 bp

>AT244590 NZ_CP097048:2593781-2593967 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCG
AAAATCAGTAACGCAACAAGGGTTGCA

Structures

Antitoxin