Detailed information of TA system TA244580

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-RNAII/-
• Location: 2699590..2699990
• Replicon: chromosome
• Accession: NZ_CP097046
• Organism: Enterococcus faecalis strain AT29

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: M2907_RS12950
• Protein ID: WP_016619108.1
• Coordinates: 2699847..2699990 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	RNAII
Locus tag	-
Coordinates	2699590..2699736 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M2907_RS12925 (2694685)	2694685..2694900	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
M2907_RS12930 (2695039)	2695039..2696031	+	993	WP_002378862.1	biotin--[acetyl-CoA-carboxylase] ligase	-
M2907_RS12935 (2696198)	2696198..2696836	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
M2907_RS12940 (2697522)	2697522..2699138	+	1617	WP_174114069.1	phosphatase PAP2/LCP family protein	-
M2907_RS12945 (2699467)	2699467..2699616	+	150	WP_002411240.1	type I toxin-antitoxin system toxin PepG1	-
- (2699590)	2699590..2699736	-	147	NuclAT_12	-	Antitoxin
- (2699549)	2699549..2699750	-	202	NuclAT_8	-	-
M2907_RS12950 (2699847)	2699847..2699990	+	144	WP_016619108.1	putative holin-like toxin	Toxin
- (2700134)	2700134..2700183	+	50	NuclAT_16	-	-
- (2699922)	2699922..2700184	-	263	NuclAT_11	-	-
M2907_RS12955 (2700185)	2700185..2704876	-	4692	WP_174114070.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5191.13 Da
• Isoelectric Point: 8.6626

>T244580 WP_016619108.1 NZ_CP097046:2699847-2699990 [Enterococcus faecalis]
MNVSTKTYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

>T244580 NZ_CP097046:2699847-2699990 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAACCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 147 bp

>AT244580 NZ_CP097046:c2699736-2699590 [Enterococcus faecalis]
TTGTGCTATAATAGCAATGAAAAGAGAGATATGCTGTAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCTTT
TTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAA

Structures

Antitoxin