244572

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2608497..2608771 Replicon chromosome
Accession NZ_CP097046
Organism Enterococcus faecalis strain AT29

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag M2907_RS12525 Protein ID WP_002392696.1
Coordinates 2608628..2608771 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2608497..2608695 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2907_RS12505 (2603502) 2603502..2604215 - 714 WP_002354877.1 trehalose operon repressor -
M2907_RS12510 (2604476) 2604476..2607220 + 2745 WP_174113967.1 glycoside hydrolase family 65 protein -
M2907_RS12515 (2607235) 2607235..2607885 + 651 WP_002354875.1 beta-phosphoglucomutase -
- (2607954) 2607954..2608087 + 134 NuclAT_15 - -
- (2608134) 2608134..2608279 + 146 NuclAT_13 - -
- (2608134) 2608134..2608320 + 187 NuclAT_10 - -
M2907_RS12520 (2608253) 2608253..2608396 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 -
- (2608509) 2608509..2608654 + 146 NuclAT_14 - -
- (2608497) 2608497..2608695 + 199 NuclAT_9 - Antitoxin
M2907_RS12525 (2608628) 2608628..2608771 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 Toxin
M2907_RS13775 (2609179) 2609179..2609304 - 126 WP_002383214.1 hypothetical protein -
M2907_RS12530 (2609509) 2609509..2609715 + 207 WP_258075960.1 CPBP family intramembrane metalloprotease -
M2907_RS12535 (2609768) 2609768..2610739 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
M2907_RS12540 (2610914) 2610914..2611351 - 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
M2907_RS12545 (2611484) 2611484..2612038 - 555 WP_002354869.1 Maf family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T244572 WP_002392696.1 NZ_CP097046:c2608771-2608628 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 199 bp

>AT244572 NZ_CP097046:2608497-2608695 [Enterococcus faecalis]
TTTTTAGGGAAATGTGCTATAATGAAAATGAAAAGAGAGATATGCTTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGA
CGGTGACCGATTATATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAATT
TCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References