Detailed information of TA system TA244565

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2533631..2533891
• Replicon: chromosome
• Accession: NZ_CP097046
• Organism: Enterococcus faecalis strain AT29

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: M2907_RS12175
• Protein ID: WP_224561205.1
• Coordinates: 2533790..2533891 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2533631..2533841 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M2907_RS12145 (2528883)	2528883..2529836	-	954	WP_174114190.1	siderophore ABC transporter substrate-binding protein	-
M2907_RS12150 (2529875)	2529875..2530630	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
M2907_RS12155 (2530627)	2530627..2531592	-	966	WP_002354961.1	iron chelate uptake ABC transporter family permease subunit	-
M2907_RS12160 (2531589)	2531589..2532536	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
M2907_RS12165 (2532721)	2532721..2533173	+	453	WP_002354958.1	YueI family protein	-
- (2533199)	2533199..2533406	+	208	NuclAT_4	-	-
- (2533236)	2533236..2533410	+	175	NuclAT_7	-	-
M2907_RS12170 (2533355)	2533355..2533456	-	102	WP_021164441.1	putative holin-like toxin	-
- (2533631)	2533631..2533841	+	211	NuclAT_5	-	Antitoxin
- (2533665)	2533665..2533845	+	181	NuclAT_6	-	-
M2907_RS12175 (2533790)	2533790..2533891	-	102	WP_224561205.1	putative holin-like toxin	Toxin
M2907_RS12180 (2534081)	2534081..2536351	-	2271	WP_002368430.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
M2907_RS12185 (2536522)	2536522..2537028	+	507	WP_174114188.1	cysteine hydrolase family protein	-
M2907_RS12190 (2537218)	2537218..2538114	+	897	WP_002368434.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3629.37 Da
• Isoelectric Point: 4.5869

>T244565 WP_224561205.1 NZ_CP097046:c2533891-2533790 [Enterococcus faecalis]
MSIEATLELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 211 bp

>AT244565 NZ_CP097046:2533631-2533841 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACA
CCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGT
TATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin