Detailed information of TA system TA244537

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2718213..2718549
• Replicon: chromosome
• Accession: NZ_CP097038
• Organism: Enterococcus faecalis strain AT39

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: E2Z0W4
• Locus tag: M2911_RS12910
• Protein ID: WP_002381035.1
• Coordinates: 2718213..2718356 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2718500..2718549 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M2911_RS12895	2713929..2714561	-	633	WP_002358972.1	RloB family protein	-
M2911_RS12900	2714570..2715865	-	1296	WP_248882009.1	ATP-binding protein	-
M2911_RS12905	2716327..2717943	+	1617	WP_002406969.1	phosphatase PAP2/LCP family protein	-
M2911_RS12910	2718213..2718356	+	144	WP_002381035.1	putative holin-like toxin	Toxin
-	2718500..2718549	+	50	-	-	Antitoxin
M2911_RS12915	2718551..2721550	-	3000	WP_033786695.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5202.20 Da
• Isoelectric Point: 10.0041

>T244537 WP_002381035.1 NZ_CP097038:2718213-2718356 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 50 bp

>AT244537 NZ_CP097038:2718500-2718549 [Enterococcus faecalis]
AATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATT

Structures

Toxin

• AlphaFold DB: A0A2Z6BWH2

Antitoxin