Detailed information of TA system TA244518

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2680536..2680873
• Replicon: chromosome
• Accession: NZ_CP097034
• Organism: Enterococcus faecalis strain AT40b

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A1J6YG70
• Locus tag: M2913_RS13030
• Protein ID: WP_002396786.1
• Coordinates: 2680536..2680679 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2680611..2680873 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M2913_RS13010	2675752..2675967	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
M2913_RS13015	2676106..2677098	+	993	WP_002378862.1	biotin--[acetyl-CoA-carboxylase] ligase	-
M2913_RS13020	2677265..2677903	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
M2913_RS13025	2678588..2680204	+	1617	WP_002378864.1	phosphatase PAP2/LCP family protein	-
M2913_RS13030	2680536..2680679	+	144	WP_002396786.1	putative holin-like toxin	Toxin
-	2680611..2680873	-	263	-	-	Antitoxin
M2913_RS13035	2680874..2685565	-	4692	WP_002378865.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5203.19 Da
• Isoelectric Point: 8.6626

>T244518 WP_002396786.1 NZ_CP097034:2680536-2680679 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 263 bp

>AT244518 NZ_CP097034:c2680873-2680611 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A1J6YG70

Antitoxin